3APT
properties and crystal structure of methylenetetrahydrofolate reductase from Thermus thermophilus HB8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004489 | molecular_function | methylenetetrahydrofolate reductase [NAD(P)H] activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006555 | biological_process | L-methionine metabolic process |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0071949 | molecular_function | FAD binding |
| A | 0106312 | molecular_function | methylenetetrahydrofolate reductase (NADH) activity |
| B | 0004489 | molecular_function | methylenetetrahydrofolate reductase [NAD(P)H] activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006555 | biological_process | L-methionine metabolic process |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0071949 | molecular_function | FAD binding |
| B | 0106312 | molecular_function | methylenetetrahydrofolate reductase (NADH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE FAD A 311 |
| Chain | Residue |
| A | THR49 |
| A | ALA127 |
| A | ALA147 |
| A | TYR149 |
| A | HIS153 |
| A | GLU155 |
| A | SER156 |
| A | HIS165 |
| A | LYS169 |
| A | ILE178 |
| A | GLN180 |
| A | TYR50 |
| A | TYR272 |
| A | HOH329 |
| A | HOH357 |
| A | HOH368 |
| A | HOH387 |
| A | HOH390 |
| A | HOH397 |
| A | HOH418 |
| A | HOH450 |
| A | HOH473 |
| A | HIS77 |
| A | HOH492 |
| A | HOH502 |
| A | LEU104 |
| A | LEU106 |
| A | ARG107 |
| A | GLY108 |
| A | ASP109 |
| A | TYR126 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 311 |
| Chain | Residue |
| B | GLU18 |
| B | LEU104 |
| B | ASP109 |
| B | PRO110 |
| B | ILE178 |
| B | HIS270 |
| B | TYR272 |
