3APT

properties and crystal structure of methylenetetrahydrofolate reductase from Thermus thermophilus HB8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004489	molecular_function	methylenetetrahydrofolate reductase (NAD(P)H) activity
A	0005829	cellular_component	cytosol
A	0006555	biological_process	methionine metabolic process
A	0009086	biological_process	methionine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0035999	biological_process	tetrahydrofolate interconversion
A	0071949	molecular_function	FAD binding
A	0106312	molecular_function	methylenetetrahydrofolate reductase (NADH) activity
B	0000166	molecular_function	nucleotide binding
B	0004489	molecular_function	methylenetetrahydrofolate reductase (NAD(P)H) activity
B	0005829	cellular_component	cytosol
B	0006555	biological_process	methionine metabolic process
B	0009086	biological_process	methionine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0035999	biological_process	tetrahydrofolate interconversion
B	0071949	molecular_function	FAD binding
B	0106312	molecular_function	methylenetetrahydrofolate reductase (NADH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD A 311

Chain	Residue
A	THR49
A	ALA127
A	ALA147
A	TYR149
A	HIS153
A	GLU155
A	SER156
A	HIS165
A	LYS169
A	ILE178
A	GLN180
A	TYR50
A	TYR272
A	HOH329
A	HOH357
A	HOH368
A	HOH387
A	HOH390
A	HOH397
A	HOH418
A	HOH450
A	HOH473
A	HIS77
A	HOH492
A	HOH502
A	LEU104
A	LEU106
A	ARG107
A	GLY108
A	ASP109
A	TYR126

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT B 311

Chain	Residue
B	GLU18
B	LEU104
B	ASP109
B	PRO110
B	ILE178
B	HIS270
B	TYR272

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