3AP3
Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006478 | biological_process | peptidyl-tyrosine sulfation |
| A | 0008476 | molecular_function | protein-tyrosine sulfotransferase activity |
| B | 0006478 | biological_process | peptidyl-tyrosine sulfation |
| B | 0008476 | molecular_function | protein-tyrosine sulfotransferase activity |
| C | 0006478 | biological_process | peptidyl-tyrosine sulfation |
| C | 0008476 | molecular_function | protein-tyrosine sulfotransferase activity |
| D | 0006478 | biological_process | peptidyl-tyrosine sulfation |
| D | 0008476 | molecular_function | protein-tyrosine sulfotransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE A3P A 1 |
| Chain | Residue |
| A | ARG78 |
| A | TYR238 |
| A | SER285 |
| A | GLN288 |
| A | VAL289 |
| A | LYS291 |
| A | PRO292 |
| A | VAL293 |
| A | ASN294 |
| A | ALA297 |
| A | LYS300 |
| A | SER79 |
| A | GLY80 |
| A | THR81 |
| A | THR82 |
| A | LEU83 |
| A | ARG183 |
| A | SER191 |
| A | ARG195 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE A3P B 1 |
| Chain | Residue |
| B | ARG78 |
| B | SER79 |
| B | GLY80 |
| B | THR81 |
| B | THR82 |
| B | ARG183 |
| B | SER191 |
| B | ARG195 |
| B | TYR238 |
| B | VAL289 |
| B | LYS291 |
| B | PRO292 |
| B | ASN294 |
| B | ALA297 |
| B | LYS300 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE A3P C 1 |
| Chain | Residue |
| C | PRO77 |
| C | ARG78 |
| C | SER79 |
| C | GLY80 |
| C | THR81 |
| C | THR82 |
| C | ARG183 |
| C | SER191 |
| C | ARG195 |
| C | TYR238 |
| C | SER285 |
| C | GLN288 |
| C | VAL289 |
| C | LYS291 |
| C | PRO292 |
| C | VAL293 |
| C | ASN294 |
| C | ALA297 |
| C | LYS300 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE A3P D 1 |
| Chain | Residue |
| D | ARG78 |
| D | SER79 |
| D | GLY80 |
| D | THR81 |
| D | THR82 |
| D | LEU83 |
| D | ARG183 |
| D | SER191 |
| D | ARG195 |
| D | TYR238 |
| D | SER285 |
| D | GLN288 |
| D | VAL289 |
| D | LYS291 |
| D | PRO292 |
| D | ASN294 |
| D | ALA297 |
| D | LYS300 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:23481380 |
| Chain | Residue | Details |
| A | GLU99 | |
| B | GLU99 | |
| C | GLU99 | |
| D | GLU99 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0007744|PDB:3AP1, ECO:0007744|PDB:3AP2, ECO:0007744|PDB:3AP3 |
| Chain | Residue | Details |
| A | ARG78 | |
| A | SER285 | |
| B | ARG78 | |
| B | SER285 | |
| C | ARG78 | |
| C | SER285 | |
| D | ARG78 | |
| D | SER285 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:23481380, ECO:0007744|PDB:3AP1, ECO:0007744|PDB:3AP2, ECO:0007744|PDB:3AP3 |
| Chain | Residue | Details |
| A | ARG183 | |
| B | LYS300 | |
| C | ARG183 | |
| C | SER191 | |
| C | ARG195 | |
| C | TYR238 | |
| C | LYS300 | |
| D | ARG183 | |
| D | SER191 | |
| D | ARG195 | |
| D | TYR238 | |
| A | SER191 | |
| D | LYS300 | |
| A | ARG195 | |
| A | TYR238 | |
| A | LYS300 | |
| B | ARG183 | |
| B | SER191 | |
| B | ARG195 | |
| B | TYR238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:23481380 |
| Chain | Residue | Details |
| A | LYS158 | |
| A | SER285 | |
| B | LYS158 | |
| B | SER285 | |
| C | LYS158 | |
| C | SER285 | |
| D | LYS158 | |
| D | SER285 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN343 | |
| A | ASN368 | |
| B | ASN343 | |
| B | ASN368 | |
| C | ASN343 | |
| C | ASN368 | |
| D | ASN343 | |
| D | ASN368 |
