3ANX
Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004766 | molecular_function | spermidine synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0008295 | biological_process | spermidine biosynthetic process |
| A | 0010487 | molecular_function | thermospermine synthase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016768 | molecular_function | spermine synthase activity |
| A | 0043918 | molecular_function | cadaverine aminopropyltransferase activity |
| A | 0043919 | molecular_function | agmatine aminopropyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004766 | molecular_function | spermidine synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0008295 | biological_process | spermidine biosynthetic process |
| B | 0010487 | molecular_function | thermospermine synthase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016768 | molecular_function | spermine synthase activity |
| B | 0043918 | molecular_function | cadaverine aminopropyltransferase activity |
| B | 0043919 | molecular_function | agmatine aminopropyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MTA A 315 |
| Chain | Residue |
| A | GLN33 |
| A | ALA141 |
| A | ASP158 |
| A | THR160 |
| A | LEU172 |
| A | GLN54 |
| A | GLY85 |
| A | GLY86 |
| A | GLY87 |
| A | ASP108 |
| A | ILE109 |
| A | LEU113 |
| A | ASP140 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MTA B 315 |
| Chain | Residue |
| B | GLN33 |
| B | GLY85 |
| B | GLY86 |
| B | GLY87 |
| B | VAL107 |
| B | ASP108 |
| B | ILE109 |
| B | LEU113 |
| B | ALA141 |
| B | ASP158 |
| B | LEU159 |
| B | LEU172 |
Functional Information from PROSITE/UniProt
| site_id | PS01330 |
| Number of Residues | 14 |
| Details | PABS_1 Polyamine biosynthesis (PABS) domain signature. VLIVGGGeGatLrE |
| Chain | Residue | Details |
| A | VAL81-GLU94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00198 |
| Chain | Residue | Details |
| A | ASP158 | |
| B | ASP158 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000269|PubMed:21458463, ECO:0007744|PDB:3ANX |
| Chain | Residue | Details |
| A | GLN33 | |
| A | ASP108 | |
| A | ASP140 | |
| B | GLN33 | |
| B | ASP108 | |
| B | ASP140 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00198 |
| Chain | Residue | Details |
| A | HIS64 | |
| A | GLU88 | |
| A | ASP158 | |
| A | PRO168 | |
| B | HIS64 | |
| B | GLU88 | |
| B | ASP158 | |
| B | PRO168 |
