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3AM8

Crystal Structure of a Human Major Histocompatibilty complex

Functional Information from GO Data
ChainGOidnamespacecontents
C0000139cellular_componentGolgi membrane
C0001913biological_processT cell mediated cytotoxicity
C0001916biological_processpositive regulation of T cell mediated cytotoxicity
C0002237biological_processresponse to molecule of bacterial origin
C0002376biological_processimmune system process
C0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
C0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
C0002502biological_processpeptide antigen assembly with MHC class I protein complex
C0002503biological_processpeptide antigen assembly with MHC class II protein complex
C0002726biological_processpositive regulation of T cell cytokine production
C0005198molecular_functionstructural molecule activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005765cellular_componentlysosomal membrane
C0005783cellular_componentendoplasmic reticulum
C0005788cellular_componentendoplasmic reticulum lumen
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006826biological_processiron ion transport
C0006879biological_processintracellular iron ion homeostasis
C0006955biological_processimmune response
C0007608biological_processsensory perception of smell
C0007611biological_processlearning or memory
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0010038biological_processresponse to metal ion
C0010977biological_processnegative regulation of neuron projection development
C0012507cellular_componentER to Golgi transport vesicle membrane
C0016020cellular_componentmembrane
C0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
C0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
C0023026molecular_functionMHC class II protein complex binding
C0030670cellular_componentphagocytic vesicle membrane
C0031901cellular_componentearly endosome membrane
C0031902cellular_componentlate endosome membrane
C0031905cellular_componentearly endosome lumen
C0033077biological_processT cell differentiation in thymus
C0033572biological_processtransferrin transport
C0034756biological_processregulation of iron ion transport
C0034757biological_processnegative regulation of iron ion transport
C0035580cellular_componentspecific granule lumen
C0042026biological_processprotein refolding
C0042605molecular_functionpeptide antigen binding
C0042612cellular_componentMHC class I protein complex
C0042613cellular_componentMHC class II protein complex
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0042824cellular_componentMHC class I peptide loading complex
C0045646biological_processregulation of erythrocyte differentiation
C0048260biological_processpositive regulation of receptor-mediated endocytosis
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0050680biological_processnegative regulation of epithelial cell proliferation
C0050768biological_processnegative regulation of neurogenesis
C0050778biological_processpositive regulation of immune response
C0050870biological_processpositive regulation of T cell activation
C0051289biological_processprotein homotetramerization
C0055038cellular_componentrecycling endosome membrane
C0060586biological_processmulticellular organismal-level iron ion homeostasis
C0070062cellular_componentextracellular exosome
C0071281biological_processcellular response to iron ion
C0071283biological_processcellular response to iron(III) ion
C0071316biological_processcellular response to nicotine
C1904724cellular_componenttertiary granule lumen
C1990000biological_processamyloid fibril formation
C1990712cellular_componentHFE-transferrin receptor complex
C2000774biological_processpositive regulation of cellular senescence
C2000978biological_processnegative regulation of forebrain neuron differentiation
D0000139cellular_componentGolgi membrane
D0001913biological_processT cell mediated cytotoxicity
D0001916biological_processpositive regulation of T cell mediated cytotoxicity
D0002237biological_processresponse to molecule of bacterial origin
D0002376biological_processimmune system process
D0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
D0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D0002502biological_processpeptide antigen assembly with MHC class I protein complex
D0002503biological_processpeptide antigen assembly with MHC class II protein complex
D0002726biological_processpositive regulation of T cell cytokine production
D0005198molecular_functionstructural molecule activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005765cellular_componentlysosomal membrane
D0005783cellular_componentendoplasmic reticulum
D0005788cellular_componentendoplasmic reticulum lumen
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006826biological_processiron ion transport
D0006879biological_processintracellular iron ion homeostasis
D0006955biological_processimmune response
D0007608biological_processsensory perception of smell
D0007611biological_processlearning or memory
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0010038biological_processresponse to metal ion
D0010977biological_processnegative regulation of neuron projection development
D0012507cellular_componentER to Golgi transport vesicle membrane
D0016020cellular_componentmembrane
D0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
D0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
D0023026molecular_functionMHC class II protein complex binding
D0030670cellular_componentphagocytic vesicle membrane
D0031901cellular_componentearly endosome membrane
D0031902cellular_componentlate endosome membrane
D0031905cellular_componentearly endosome lumen
D0033077biological_processT cell differentiation in thymus
D0033572biological_processtransferrin transport
D0034756biological_processregulation of iron ion transport
D0034757biological_processnegative regulation of iron ion transport
D0035580cellular_componentspecific granule lumen
D0042026biological_processprotein refolding
D0042605molecular_functionpeptide antigen binding
D0042612cellular_componentMHC class I protein complex
D0042613cellular_componentMHC class II protein complex
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042824cellular_componentMHC class I peptide loading complex
D0045646biological_processregulation of erythrocyte differentiation
D0048260biological_processpositive regulation of receptor-mediated endocytosis
D0048261biological_processnegative regulation of receptor-mediated endocytosis
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050768biological_processnegative regulation of neurogenesis
D0050778biological_processpositive regulation of immune response
D0050870biological_processpositive regulation of T cell activation
D0051289biological_processprotein homotetramerization
D0055038cellular_componentrecycling endosome membrane
D0060586biological_processmulticellular organismal-level iron ion homeostasis
D0070062cellular_componentextracellular exosome
D0071281biological_processcellular response to iron ion
D0071283biological_processcellular response to iron(III) ion
D0071316biological_processcellular response to nicotine
D1904724cellular_componenttertiary granule lumen
D1990000biological_processamyloid fibril formation
D1990712cellular_componentHFE-transferrin receptor complex
D2000774biological_processpositive regulation of cellular senescence
D2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
CTYR78-HIS84
ATYR257-HIS263

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
ChainResidueDetails
CGLN2
DGLN2

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
ChainResidueDetails
CILE1
DILE1

site_idSWS_FT_FI3
Number of Residues12
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
ChainResidueDetails
CLYS19
DLYS58
DLYS91
DLYS94
CLYS41
CLYS48
CLYS58
CLYS91
CLYS94
DLYS19
DLYS41
DLYS48

site_idSWS_FT_FI4
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:18339401
ChainResidueDetails
AASN77
BSER143
BLYS146
BGLN156
BTYR159
BTYR171
ATYR84
ASER143
ALYS146
AGLN156
ATYR159
ATYR171
BASN77
BTYR84

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973
ChainResidueDetails
AASN86
BASN86

237423

PDB entries from 2025-06-11

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