3AKM

X-ray structure of iFABP from human and rat with bound fluorescent fatty acid analogue

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005902	cellular_component	microvillus
A	0006631	biological_process	fatty acid metabolic process
A	0008289	molecular_function	lipid binding
A	0015908	biological_process	fatty acid transport
A	0015909	biological_process	long-chain fatty acid transport
A	0036041	molecular_function	long-chain fatty acid binding
A	0045179	cellular_component	apical cortex
A	0050892	biological_process	intestinal absorption
A	0098856	biological_process	intestinal lipid absorption
B	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005902	cellular_component	microvillus
B	0006631	biological_process	fatty acid metabolic process
B	0008289	molecular_function	lipid binding
B	0015908	biological_process	fatty acid transport
B	0015909	biological_process	long-chain fatty acid transport
B	0036041	molecular_function	long-chain fatty acid binding
B	0045179	cellular_component	apical cortex
B	0050892	biological_process	intestinal absorption
B	0098856	biological_process	intestinal lipid absorption
C	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005902	cellular_component	microvillus
C	0006631	biological_process	fatty acid metabolic process
C	0008289	molecular_function	lipid binding
C	0015908	biological_process	fatty acid transport
C	0015909	biological_process	long-chain fatty acid transport
C	0036041	molecular_function	long-chain fatty acid binding
C	0045179	cellular_component	apical cortex
C	0050892	biological_process	intestinal absorption
C	0098856	biological_process	intestinal lipid absorption
D	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005902	cellular_component	microvillus
D	0006631	biological_process	fatty acid metabolic process
D	0008289	molecular_function	lipid binding
D	0015908	biological_process	fatty acid transport
D	0015909	biological_process	long-chain fatty acid transport
D	0036041	molecular_function	long-chain fatty acid binding
D	0045179	cellular_component	apical cortex
D	0050892	biological_process	intestinal absorption
D	0098856	biological_process	intestinal lipid absorption

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 11D A 132

Chain	Residue
A	TYR14
A	LEU72
A	ALA73
A	ASP74
A	LEU78
A	TRP82
A	PHE93
A	ARG106
A	PHE17
A	MET18
A	MET21
A	VAL23
A	ALA31
A	GLU51
A	PHE55
A	PHE62

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 133

Chain	Residue
A	GLN115

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 11D B 132

Chain	Residue
B	TYR14
B	PHE17
B	MET18
B	MET21
B	ALA31
B	GLU51
B	PHE55
B	VAL60
B	PHE62
B	PHE68
B	TYR70
B	LEU72
B	ALA73
B	ASP74
B	TRP82
B	PHE93
B	ARG106
B	TYR117

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG B 133

Chain	Residue
B	GLN115

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 11D C 132

Chain	Residue
C	TYR14
C	PHE17
C	MET18
C	MET21
C	VAL23
C	LYS27
C	ALA31
C	VAL49
C	GLU51
C	TYR70
C	LEU72
C	ASP74
C	TRP82
C	ARG106

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG C 133

Chain	Residue
C	GLN115

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 11D D 132

Chain	Residue
D	TYR14
D	PHE17
D	MET18
D	MET21
D	VAL23
D	ALA31
D	VAL49
D	GLU51
D	PHE55
D	PHE62
D	TYR70
D	LEU72
D	ALA73
D	ASP74
D	TRP82
D	ARG106

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 133

Chain	Residue
D	GLN115
D	TYR117

---

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. STWkVdrSeNYDkFMEKM

Chain	Residue	Details
A	SER4-MET21

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P02693","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P02693","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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