3AJM

Crystal structure of programmed cell death 10 in complex with inositol 1,3,4,5-tetrakisphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001525	biological_process	angiogenesis
A	0003158	biological_process	endothelium development
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006915	biological_process	apoptotic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0010628	biological_process	positive regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0019901	molecular_function	protein kinase binding
A	0030335	biological_process	positive regulation of cell migration
A	0032874	biological_process	positive regulation of stress-activated MAPK cascade
A	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
A	0035023	biological_process	regulation of Rho protein signal transduction
A	0035556	biological_process	intracellular signal transduction
A	0036481	biological_process	intrinsic apoptotic signaling pathway in response to hydrogen peroxide
A	0042803	molecular_function	protein homodimerization activity
A	0043066	biological_process	negative regulation of apoptotic process
A	0043149	biological_process	stress fiber assembly
A	0043406	biological_process	positive regulation of MAP kinase activity
A	0044319	biological_process	wound healing, spreading of cells
A	0045747	biological_process	positive regulation of Notch signaling pathway
A	0045765	biological_process	regulation of angiogenesis
A	0050821	biological_process	protein stabilization
A	0051683	biological_process	establishment of Golgi localization
A	0070062	cellular_component	extracellular exosome
A	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
A	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
A	0090168	biological_process	Golgi reassembly
A	0090316	biological_process	positive regulation of intracellular protein transport
A	0090443	cellular_component	FAR/SIN/STRIPAK complex
A	1903588	biological_process	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
B	0000139	cellular_component	Golgi membrane
B	0001525	biological_process	angiogenesis
B	0003158	biological_process	endothelium development
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006915	biological_process	apoptotic process
B	0008284	biological_process	positive regulation of cell population proliferation
B	0010628	biological_process	positive regulation of gene expression
B	0010629	biological_process	negative regulation of gene expression
B	0019901	molecular_function	protein kinase binding
B	0030335	biological_process	positive regulation of cell migration
B	0032874	biological_process	positive regulation of stress-activated MAPK cascade
B	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
B	0035023	biological_process	regulation of Rho protein signal transduction
B	0035556	biological_process	intracellular signal transduction
B	0036481	biological_process	intrinsic apoptotic signaling pathway in response to hydrogen peroxide
B	0042803	molecular_function	protein homodimerization activity
B	0043066	biological_process	negative regulation of apoptotic process
B	0043149	biological_process	stress fiber assembly
B	0043406	biological_process	positive regulation of MAP kinase activity
B	0044319	biological_process	wound healing, spreading of cells
B	0045747	biological_process	positive regulation of Notch signaling pathway
B	0045765	biological_process	regulation of angiogenesis
B	0050821	biological_process	protein stabilization
B	0051683	biological_process	establishment of Golgi localization
B	0070062	cellular_component	extracellular exosome
B	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
B	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
B	0090168	biological_process	Golgi reassembly
B	0090316	biological_process	positive regulation of intracellular protein transport
B	0090443	cellular_component	FAR/SIN/STRIPAK complex
B	1903588	biological_process	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 4IP A 1

Chain	Residue
A	LYS70
A	LYS186
B	LYS70
B	GLY185
B	LYS186

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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