3AEP
Reaction intermediate structure of Entamoeba histolytica methionine gamma-lyase 1 containing alpha-amino-alpha, beta-butenoic acid-pyridoxal-5'-phosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016846 | molecular_function | carbon-sulfur lyase activity |
| A | 0019346 | biological_process | transsulfuration |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016846 | molecular_function | carbon-sulfur lyase activity |
| B | 0019346 | biological_process | transsulfuration |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0009086 | biological_process | methionine biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016846 | molecular_function | carbon-sulfur lyase activity |
| C | 0019346 | biological_process | transsulfuration |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003962 | molecular_function | cystathionine gamma-synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0009086 | biological_process | methionine biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016846 | molecular_function | carbon-sulfur lyase activity |
| D | 0019346 | biological_process | transsulfuration |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 4LM A 2001 |
| Chain | Residue |
| A | SER82 |
| A | SER332 |
| A | THR347 |
| A | ARG367 |
| A | MEE2002 |
| D | TYR1553 |
| D | ARG1555 |
| A | GLY83 |
| A | MET84 |
| A | TYR108 |
| A | ASN155 |
| A | ASP180 |
| A | SER202 |
| A | SER204 |
| A | LYS205 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MEE A 2002 |
| Chain | Residue |
| A | TYR108 |
| A | THR347 |
| A | 4LM2001 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 4LM B 2003 |
| Chain | Residue |
| B | SER582 |
| B | GLY583 |
| B | MET584 |
| B | TYR608 |
| B | GLU651 |
| B | ASN655 |
| B | ASP680 |
| B | THR682 |
| B | SER702 |
| B | SER704 |
| B | LYS705 |
| B | ILE714 |
| B | SER832 |
| B | THR847 |
| B | ARG867 |
| C | TYR1053 |
| C | ARG1055 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 4LM C 2004 |
| Chain | Residue |
| B | TYR553 |
| B | ARG555 |
| C | SER1082 |
| C | GLY1083 |
| C | MET1084 |
| C | TYR1108 |
| C | ASN1155 |
| C | ASP1180 |
| C | THR1182 |
| C | SER1202 |
| C | SER1204 |
| C | LYS1205 |
| C | GLY1215 |
| C | SER1332 |
| C | LEU1333 |
| C | THR1347 |
| C | ARG1367 |
| C | MEE2005 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MEE C 2005 |
| Chain | Residue |
| C | TYR1108 |
| C | 4LM2004 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 4LM D 2006 |
| Chain | Residue |
| A | TYR53 |
| A | ARG55 |
| D | SER1582 |
| D | GLY1583 |
| D | MET1584 |
| D | TYR1608 |
| D | ASN1655 |
| D | ASP1680 |
| D | THR1682 |
| D | SER1702 |
| D | SER1704 |
| D | LYS1705 |
| D | ILE1714 |
| D | GLY1715 |
| D | SER1832 |
| D | THR1847 |
| D | ARG1867 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2007 |
| Chain | Residue |
| A | ARG176 |
| A | HOH3655 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2008 |
| Chain | Residue |
| B | ARG676 |
| B | HOH3630 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2009 |
| Chain | Residue |
| C | ARG1176 |
| C | HOH3423 |
| C | HOH3664 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2010 |
| Chain | Residue |
| D | ARG1676 |
| D | HOH3248 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 2011 |
| Chain | Residue |
| A | LYS312 |
| A | HOH3124 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL C 2012 |
| Chain | Residue |
| C | HOH3564 |
| C | HOH3592 |
