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3ACD

Crystal structure of hypoxanthine-guanine phosphoribosyltransferase with IMP from Thermus thermophilus HB8

Replaces:  2YWU
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0004422molecular_functionhypoxanthine phosphoribosyltransferase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006166biological_processpurine ribonucleoside salvage
A0006177biological_processGMP biosynthetic process
A0006178biological_processguanine salvage
A0006188biological_processIMP biosynthetic process
A0016740molecular_functiontransferase activity
A0016757molecular_functionglycosyltransferase activity
A0032263biological_processGMP salvage
A0032264biological_processIMP salvage
A0043101biological_processpurine-containing compound salvage
A0046100biological_processhypoxanthine metabolic process
A0046872molecular_functionmetal ion binding
A0052657molecular_functionguanine phosphoribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE IMP A 552
ChainResidue
AGLU102
AALA154
ATYR155
AVAL156
AHOH609
AHOH612
AHOH634
AHOH639
AHOH640
AHOH655
AHOH696
AASP103
AHOH720
AILE104
AASP106
ATHR107
AGLY108
ALEU109
ATHR110
ALYS134

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DIO A 591
ChainResidue
AASP33
ATYR34
ALYS37
ASER125
AARG127

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DIO A 592
ChainResidue
AMET4
APHE5
APRO60
ALEU61
APRO62
ALEU170
AHOH631

Functional Information from PROSITE/UniProt
site_idPS00103
Number of Residues13
DetailsPUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VIVVEDIVDTGlT
ChainResidueDetails
AVAL98-THR110

237992

PDB entries from 2025-06-25

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