3ACA
Crystal structure of human NUDT5 complexed with 8-oxo-dADP and manganese
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 3 |
| Chain | Residue |
| A | 8DD2 |
| A | MN4 |
| A | ALA96 |
| A | GLU116 |
| A | HOH387 |
| A | HOH388 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 4 |
| Chain | Residue |
| A | GLU116 |
| A | HOH326 |
| A | HOH340 |
| A | 8DD2 |
| A | MN3 |
| A | GLU112 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN A 5 |
| Chain | Residue |
| A | 8DD2 |
| A | GLU112 |
| A | HOH307 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 8DD A 2 |
| Chain | Residue |
| A | MN3 |
| A | MN4 |
| A | MN5 |
| A | TRP28 |
| A | ARG51 |
| A | ARG84 |
| A | ALA96 |
| A | GLY97 |
| A | LEU98 |
| A | GLU112 |
| A | HOH340 |
| A | HOH407 |
| B | TRP46 |
| B | GLU47 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 1 |
| Chain | Residue |
| B | MN2 |
| B | ALA96 |
| B | GLU116 |
| B | 8DD209 |
| B | HOH518 |
| B | HOH519 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MN B 2 |
| Chain | Residue |
| B | MN1 |
| B | ALA96 |
| B | GLU112 |
| B | GLU116 |
| B | GLU166 |
| B | 8DD209 |
| B | HOH452 |
| B | HOH491 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 8DD B 209 |
| Chain | Residue |
| A | THR45 |
| A | TRP46 |
| A | GLU47 |
| B | MN1 |
| B | MN2 |
| B | TRP28 |
| B | ARG51 |
| B | ARG84 |
| B | ALA96 |
| B | LEU98 |
| B | GLU166 |
| B | HOH491 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GliddgEtpeaAAlRELeEEtG |
| Chain | Residue | Details |
| A | GLY97-GLY118 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 280 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Motif: {"description":"Nudix box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"17052728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18462755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21768126","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17052728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18462755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21768126","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"17052728","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"27257257","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
