3ABR

Crystal structure of ethanolamine ammonia-lyase from Escherichia coli complexed with CN-Cbl (substrate-free form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0008851	molecular_function	ethanolamine ammonia-lyase activity
A	0009350	cellular_component	ethanolamine ammonia-lyase complex
A	0016829	molecular_function	lyase activity
A	0031419	molecular_function	cobalamin binding
A	0031469	cellular_component	bacterial microcompartment
A	0031471	cellular_component	ethanolamine degradation polyhedral organelle
A	0046336	biological_process	ethanolamine catabolic process
B	0006520	biological_process	amino acid metabolic process
B	0008851	molecular_function	ethanolamine ammonia-lyase activity
B	0009350	cellular_component	ethanolamine ammonia-lyase complex
B	0016829	molecular_function	lyase activity
B	0031419	molecular_function	cobalamin binding
B	0031469	cellular_component	bacterial microcompartment
B	0031471	cellular_component	ethanolamine degradation polyhedral organelle
B	0046336	biological_process	ethanolamine catabolic process
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0008851	molecular_function	ethanolamine ammonia-lyase activity
C	0009350	cellular_component	ethanolamine ammonia-lyase complex
C	0016829	molecular_function	lyase activity
C	0031419	molecular_function	cobalamin binding
C	0031469	cellular_component	bacterial microcompartment
C	0031471	cellular_component	ethanolamine degradation polyhedral organelle
C	0046336	biological_process	ethanolamine catabolic process
D	0006520	biological_process	amino acid metabolic process
D	0008851	molecular_function	ethanolamine ammonia-lyase activity
D	0009350	cellular_component	ethanolamine ammonia-lyase complex
D	0016829	molecular_function	lyase activity
D	0031419	molecular_function	cobalamin binding
D	0031469	cellular_component	bacterial microcompartment
D	0031471	cellular_component	ethanolamine degradation polyhedral organelle
D	0046336	biological_process	ethanolamine catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 2001

Chain	Residue
A	GLY272
A	ALA273
A	ILE278
A	GLY280
A	GLU281
A	ASN282
A	CYS283
A	HOH976
C	LYS115

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 2002

Chain	Residue
A	LYS115
C	GLY272
C	ALA273
C	GLY280
C	GLU281
C	ASN282
C	CYS283
C	HOH558

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 2006

Chain	Residue
A	ASN148
A	ARG277
A	HOH466
A	HOH711
C	GLN87
C	PHE112

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 3001

Chain	Residue
A	SER295
A	TYR334
B	PRO137

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 3004

Chain	Residue
A	ILE235
A	GLY238
A	ALA239

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 3005

Chain	Residue
A	ASP398
B	VAL75
B	HOH348

---

site_id	AC7
Number of Residues	31
Details	BINDING SITE FOR RESIDUE B12 B 601

Chain	Residue
A	ASN193
A	PRO194
A	SER247
A	GLU257
A	PHE258
A	SER295
A	PHE329
A	ILE330
A	MET401
A	LEU402
A	HOH518
A	HOH524
B	ARG141
B	ARG206
B	VAL207
B	LYS208
B	GLU228
B	ARG229
B	TYR241
B	GLU253
B	ARG256
B	CYS258
B	SER260
B	ASN261
B	HOH307
B	HOH313
B	HOH320
B	HOH322
B	HOH533
B	HOH872
B	HOH895

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 3002

Chain	Residue
B	LEU96
B	SER100
B	HOH913
C	VAL45
C	HOH466

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 2003

Chain	Residue
C	ILE144
C	LYS145
C	LYS146
C	THR150
C	HOH665
C	HOH898
C	HOH936

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 2004

Chain	Residue
A	HOH590
A	HOH616
C	VAL143
C	LYS145
C	ARG316
C	GLY356
C	HOH469
C	HOH795

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 2005

Chain	Residue
C	ARG60
C	ASN61
C	HOH943

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA C 3007

Chain	Residue
C	ASP69

---

site_id	BC4
Number of Residues	29
Details	BINDING SITE FOR RESIDUE B12 D 601

Chain	Residue
D	TYR133
D	ARG141
D	ARG206
D	VAL207
D	GLU228
D	ARG229
D	TYR241
D	GLU253
D	ARG256
D	CYS258
D	SER260
D	HOH309
D	HOH310
D	HOH315
D	HOH357
D	HOH568
D	HOH735
C	PRO194
C	LEU225
C	PHE245
C	SER247
C	GLU257
C	PHE258
C	SER295
C	PHE329
C	ILE330
C	MET401
C	LEU402
C	HOH492

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA D 3003

Chain	Residue
D	SER170
D	GLU228
D	SER235
D	SER237

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA D 3006

Chain	Residue
D	SER260
D	ASN261

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29797764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---