3ABQ

Crystal structure of ethanolamine ammonia-lyase from Escherichia coli complexed with CN-Cbl and 2-amino-1-propanol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0008851	molecular_function	ethanolamine ammonia-lyase activity
A	0009350	cellular_component	ethanolamine ammonia-lyase complex
A	0016829	molecular_function	lyase activity
A	0031419	molecular_function	cobalamin binding
A	0031469	cellular_component	bacterial microcompartment
A	0031471	cellular_component	ethanolamine degradation polyhedral organelle
A	0046336	biological_process	ethanolamine catabolic process
B	0006520	biological_process	amino acid metabolic process
B	0008851	molecular_function	ethanolamine ammonia-lyase activity
B	0009350	cellular_component	ethanolamine ammonia-lyase complex
B	0016829	molecular_function	lyase activity
B	0031419	molecular_function	cobalamin binding
B	0031469	cellular_component	bacterial microcompartment
B	0031471	cellular_component	ethanolamine degradation polyhedral organelle
B	0046336	biological_process	ethanolamine catabolic process
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0008851	molecular_function	ethanolamine ammonia-lyase activity
C	0009350	cellular_component	ethanolamine ammonia-lyase complex
C	0016829	molecular_function	lyase activity
C	0031419	molecular_function	cobalamin binding
C	0031469	cellular_component	bacterial microcompartment
C	0031471	cellular_component	ethanolamine degradation polyhedral organelle
C	0046336	biological_process	ethanolamine catabolic process
D	0006520	biological_process	amino acid metabolic process
D	0008851	molecular_function	ethanolamine ammonia-lyase activity
D	0009350	cellular_component	ethanolamine ammonia-lyase complex
D	0016829	molecular_function	lyase activity
D	0031419	molecular_function	cobalamin binding
D	0031469	cellular_component	bacterial microcompartment
D	0031471	cellular_component	ethanolamine degradation polyhedral organelle
D	0046336	biological_process	ethanolamine catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 2A1 A 602

Chain	Residue
A	ARG160
A	TYR404
A	GLN162
A	ASN193
A	LEU225
A	GLU287
A	VAL326
A	PHE329
A	ASP362
A	MET392

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 2001

Chain	Residue
A	GLY272
A	ALA273
A	GLY280
A	GLU281
A	ASN282
A	CYS283
A	HOH531
A	HOH805
C	LYS115

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 2002

Chain	Residue
A	LYS115
C	GLY272
C	ALA273
C	ILE278
C	GLY280
C	GLU281
C	ASN282
C	CYS283
C	HOH520
C	HOH586

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 2006

Chain	Residue
A	ARG114
A	LYS145
A	ARG316
A	GLY356
A	HOH533
A	HOH892

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 2007

Chain	Residue
A	ILE76
A	ARG114
A	LEU117
A	THR118
A	SER119
A	SER355
A	HOH567
A	HOH577
A	HOH657
A	HOH721

---

site_id	AC6
Number of Residues	35
Details	BINDING SITE FOR RESIDUE B12 B 601

Chain	Residue
A	PRO194
A	VAL195
A	LEU225
A	ALA226
A	PHE245
A	GLN246
A	SER247
A	GLU257
A	PHE258
A	SER295
A	PHE329
A	ILE330
A	MET401
A	LEU402
A	HOH590
A	HOH639
A	HOH723
B	ARG141
B	ARG206
B	VAL207
B	GLY227
B	GLU228
B	ARG229
B	TYR241
B	GLU253
B	ARG256
B	CYS258
B	SER260
B	HOH297
B	HOH300
B	HOH411
B	HOH417
B	HOH548
B	HOH917
B	HOH1003

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2A1 C 602

Chain	Residue
C	ARG160
C	GLN162
C	ASN193
C	LEU225
C	GLU287
C	VAL326
C	PHE329
C	ASP362
C	MET392
C	LEU402
C	TYR404

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 2003

Chain	Residue
A	HOH660
C	VAL143
C	LYS145
C	ARG316
C	GLY356
C	HOH495

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 2004

Chain	Residue
C	HOH707
C	HOH969
C	ARG60
C	ASN61

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 2005

Chain	Residue
A	ASP103
A	GLU104
C	ARG441
C	LEU442

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 2008

Chain	Residue
C	LEU27
C	ALA38
C	SER40
C	ARG44
C	HOH878
C	HOH884

---

site_id	BC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE B12 D 601

Chain	Residue
C	PRO194
C	ALA226
C	GLN246
C	SER247
C	GLU257
C	PHE258
C	SER295
C	ILE330
C	MET401
C	LEU402
C	HOH553
C	HOH867
D	TYR133
D	ARG141
D	ARG206
D	VAL207
D	GLU228
D	ARG229
D	TYR241
D	GLU253
D	ARG256
D	CYS258
D	SER260
D	HOH320
D	HOH349

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29797764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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