3ABO

Crystal structure of ethanolamine ammonia-lyase from Escherichia coli complexed with CN-Cbl and ethanolamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0008851	molecular_function	ethanolamine ammonia-lyase activity
A	0009350	cellular_component	ethanolamine ammonia-lyase complex
A	0016829	molecular_function	lyase activity
A	0031419	molecular_function	cobalamin binding
A	0031469	cellular_component	bacterial microcompartment
A	0031471	cellular_component	ethanolamine degradation polyhedral organelle
A	0046336	biological_process	ethanolamine catabolic process
B	0006520	biological_process	amino acid metabolic process
B	0008851	molecular_function	ethanolamine ammonia-lyase activity
B	0009350	cellular_component	ethanolamine ammonia-lyase complex
B	0016829	molecular_function	lyase activity
B	0031419	molecular_function	cobalamin binding
B	0031469	cellular_component	bacterial microcompartment
B	0031471	cellular_component	ethanolamine degradation polyhedral organelle
B	0046336	biological_process	ethanolamine catabolic process
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0008851	molecular_function	ethanolamine ammonia-lyase activity
C	0009350	cellular_component	ethanolamine ammonia-lyase complex
C	0016829	molecular_function	lyase activity
C	0031419	molecular_function	cobalamin binding
C	0031469	cellular_component	bacterial microcompartment
C	0031471	cellular_component	ethanolamine degradation polyhedral organelle
C	0046336	biological_process	ethanolamine catabolic process
D	0006520	biological_process	amino acid metabolic process
D	0008851	molecular_function	ethanolamine ammonia-lyase activity
D	0009350	cellular_component	ethanolamine ammonia-lyase complex
D	0016829	molecular_function	lyase activity
D	0031419	molecular_function	cobalamin binding
D	0031469	cellular_component	bacterial microcompartment
D	0031471	cellular_component	ethanolamine degradation polyhedral organelle
D	0046336	biological_process	ethanolamine catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ETA A 602

Chain	Residue
A	ARG160
A	GLN162
A	ASN193
A	LEU225
A	GLU287
A	ASP362
A	MET392
A	LEU402
A	TYR404

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1011

Chain	Residue
A	GLY272
A	ALA273
A	GLY280
A	GLU281
A	ASN282
A	CYS283
A	HOH493
A	HOH529
C	ASN81
C	LYS115

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1012

Chain	Residue
A	LYS115
A	HOH606
A	HOH703
C	GLY272
C	ALA273
C	GLY280
C	GLU281
C	ASN282
C	CYS283
C	HOH522

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1014

Chain	Residue
A	ARG114
A	LYS145
A	ARG316
A	GLY356
A	HOH498
A	HOH758

---

site_id	AC5
Number of Residues	35
Details	BINDING SITE FOR RESIDUE B12 B 601

Chain	Residue
A	ASN193
A	PRO194
A	LEU225
A	ALA226
A	HIS227
A	PHE245
A	GLN246
A	SER247
A	GLU257
A	PHE258
A	SER295
A	ILE330
A	MET401
A	LEU402
A	HOH513
A	HOH557
A	HOH653
B	ARG141
B	ARG206
B	VAL207
B	LYS208
B	GLU228
B	ARG229
B	TYR241
B	GLU253
B	ARG256
B	CYS258
B	SER260
B	HOH299
B	HOH300
B	HOH309
B	HOH311
B	HOH320
B	HOH617
B	HOH707

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ETA C 602

Chain	Residue
C	ARG160
C	GLN162
C	ASN193
C	LEU225
C	GLU287
C	ASP362
C	MET392
C	LEU402
C	TYR404

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA C 1001

Chain	Residue
A	HOH684
C	ASP338
C	ASP372

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 1013

Chain	Residue
C	LYS145
C	ARG316
C	GLY356

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 1015

Chain	Residue
C	ARG60
C	ASN61
C	GLU82
C	HOH568

---

site_id	BC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE B12 D 601

Chain	Residue
C	MET401
C	LEU402
C	HOH496
C	HOH727
D	ARG141
D	ARG206
D	VAL207
D	GLY227
D	GLU228
D	ARG229
D	TYR241
D	GLU253
D	ARG256
D	CYS258
D	SER260
D	ASN261
D	HOH371
D	HOH491
D	HOH557
D	HOH618
C	PRO194
C	LEU225
C	ALA226
C	HIS227
C	GLN246
C	SER247
C	GLU257
C	PHE258
C	SER295
C	ILE330

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA D 1002

Chain	Residue
C	GLU179
D	ARG77
D	THR80

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29797764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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