3A9Z
Crystal structure of ras selenocysteine lyase in complex with selenopropionate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001887 | biological_process | selenium compound metabolic process |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0009000 | molecular_function | selenocysteine lyase activity |
| A | 0016261 | biological_process | selenocysteine catabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0032868 | biological_process | response to insulin |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0070279 | molecular_function | vitamin B6 binding |
| A | 1900408 | biological_process | negative regulation of cellular response to oxidative stress |
| A | 1902494 | cellular_component | catalytic complex |
| B | 0001887 | biological_process | selenium compound metabolic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0009000 | molecular_function | selenocysteine lyase activity |
| B | 0016261 | biological_process | selenocysteine catabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0032868 | biological_process | response to insulin |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0070279 | molecular_function | vitamin B6 binding |
| B | 1900408 | biological_process | negative regulation of cellular response to oxidative stress |
| B | 1902494 | cellular_component | catalytic complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PLP A 501 |
| Chain | Residue |
| A | GLY87 |
| A | LYS247 |
| A | HOH463 |
| A | HOH464 |
| A | HOH483 |
| A | SLP502 |
| B | GLY283 |
| B | THR284 |
| A | THR88 |
| A | HIS133 |
| A | MET182 |
| A | ASP221 |
| A | ALA223 |
| A | GLN224 |
| A | VAL244 |
| A | HIS246 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SLP A 502 |
| Chain | Residue |
| A | ASN25 |
| A | ALA26 |
| A | HIS133 |
| A | ASN186 |
| A | LYS247 |
| A | ALA373 |
| A | SER374 |
| A | CYS375 |
| A | ARG402 |
| A | PLP501 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 504 |
| Chain | Residue |
| A | ARG312 |
| A | ARG315 |
| A | ARG341 |
| A | GLY352 |
| A | SER353 |
| A | HOH540 |
| A | HOH573 |
| A | HOH590 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 505 |
| Chain | Residue |
| A | HIS310 |
| A | ASP313 |
| A | HOH630 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PLP B 501 |
| Chain | Residue |
| A | GLY283 |
| A | THR284 |
| B | GLY87 |
| B | THR88 |
| B | HIS133 |
| B | MET182 |
| B | ASP221 |
| B | ALA223 |
| B | GLN224 |
| B | VAL244 |
| B | HIS246 |
| B | LYS247 |
| B | HOH442 |
| B | HOH444 |
| B | HOH475 |
| B | SLP503 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SLP B 503 |
| Chain | Residue |
| B | ASN25 |
| B | ALA26 |
| B | HIS133 |
| B | ASN186 |
| B | LYS247 |
| B | ALA373 |
| B | SER374 |
| B | CYS375 |
| B | ARG402 |
| B | PLP501 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: S-selanylcysteine intermediate => ECO:0000269|PubMed:20164179 |
| Chain | Residue | Details |
| A | CYS375 | |
| B | CYS375 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:Q96I15 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96I15 |
| Chain | Residue | Details |
| A | SER117 | |
| B | SER117 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:20164179, ECO:0007744|PDB:3A9X, ECO:0007744|PDB:3A9Y, ECO:0007744|PDB:3A9Z |
| Chain | Residue | Details |
| A | LYS247 | |
| B | LYS247 |
