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3A7W

Crystal Structure of Trypsin complexed with (E)-4-((tetrahydro-2H-pyran-2-yloxyimino)methyl)benzimidamide (soaking 4hours)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007586biological_processdigestion
A0008236molecular_functionserine-type peptidase activity
A0046872molecular_functionmetal ion binding
A0097180cellular_componentserine protease inhibitor complex
A0097655molecular_functionserpin family protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 1
ChainResidue
AHOH5
AGLU70
AASN72
AVAL75
AGLU80
AHOH429

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 242
ChainResidue
APHE82
AHOH325
AHOH373
AVAL76
AGLU80
AGLN81

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 2
ChainResidue
ALYS167
APRO171
AGLY172
AHOH412
AHOH605
AHOH616

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE O04 A 3
ChainResidue
AGLN133
AASP189
ASER190
AGLN192
ASER195
AGLY212
AGLY214
AGLY222
AHOH360
AHOH375

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
ChainResidueDetails
AVAL54-CYS59

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS58
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues7
DetailsBINDING:
ChainResidueDetails
AGLU70
AASN72
AVAL75
AGLU80
AASP189
AGLN192
ASER195

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PDB entries from 2024-10-30

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