3A74
Lysyl-tRNA synthetase from Bacillus stearothermophilus complexed with Diadenosine Tetraphosphate (AP4A)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004824 | molecular_function | lysine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006412 | biological_process | translation |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| C | 0016740 | molecular_function | transferase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004824 | molecular_function | lysine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| D | 0016740 | molecular_function | transferase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE B4P A 494 |
| Chain | Residue |
| A | ARG253 |
| A | GLU366 |
| A | GLU370 |
| A | GLU411 |
| A | HIS412 |
| A | ASN414 |
| A | GLY467 |
| A | ARG470 |
| A | ILE481 |
| A | LYN495 |
| A | HOH508 |
| A | GLU255 |
| A | HOH511 |
| A | HOH543 |
| A | HOH747 |
| A | HOH802 |
| A | HOH885 |
| A | HOH914 |
| A | MG1000 |
| A | MG1001 |
| A | MG1002 |
| A | HOH1291 |
| A | GLY256 |
| A | HOH1300 |
| A | SER258 |
| A | ARG260 |
| A | HIS261 |
| A | ASN262 |
| A | PHE265 |
| A | MET267 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LYN A 495 |
| Chain | Residue |
| A | GLY207 |
| A | ALA229 |
| A | GLU231 |
| A | ARG253 |
| A | MET267 |
| A | GLU269 |
| A | TYR271 |
| A | ASN414 |
| A | PHE416 |
| A | GLU418 |
| A | B4P494 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1000 |
| Chain | Residue |
| A | GLU404 |
| A | GLU411 |
| A | ALA413 |
| A | ASN414 |
| A | B4P494 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1001 |
| Chain | Residue |
| A | B4P494 |
| A | HOH508 |
| A | HOH543 |
| A | HOH802 |
| A | HOH1291 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | GLU404 |
| A | GLU411 |
| A | B4P494 |
| A | HOH1300 |
| site_id | AC6 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE B4P B 494 |
| Chain | Residue |
| B | ARG253 |
| B | GLU255 |
| B | GLY256 |
| B | SER258 |
| B | ARG260 |
| B | HIS261 |
| B | ASN262 |
| B | PHE265 |
| B | MET267 |
| B | GLU366 |
| B | GLU370 |
| B | GLU411 |
| B | HIS412 |
| B | ALA413 |
| B | ASN414 |
| B | GLY467 |
| B | ARG470 |
| B | ILE481 |
| B | LYN495 |
| B | HOH502 |
| B | HOH580 |
| B | HOH864 |
| B | HOH866 |
| B | HOH868 |
| B | HOH870 |
| B | MG1100 |
| B | MG1101 |
| B | MG1102 |
| B | HOH1206 |
| C | GLN438 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LYN B 495 |
| Chain | Residue |
| B | GLY207 |
| B | ALA208 |
| B | GLU231 |
| B | ARG253 |
| B | MET267 |
| B | GLU269 |
| B | TYR271 |
| B | ASN414 |
| B | PHE416 |
| B | GLU418 |
| B | B4P494 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1100 |
| Chain | Residue |
| B | B4P494 |
| B | HOH1206 |
| B | GLU404 |
| B | GLU411 |
| B | ASN414 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1101 |
| Chain | Residue |
| B | B4P494 |
| B | HOH580 |
| B | HOH864 |
| B | HOH865 |
| B | HOH868 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1102 |
| Chain | Residue |
| B | GLU404 |
| B | GLU411 |
| B | B4P494 |
| B | HOH1206 |
| site_id | BC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE B4P C 494 |
| Chain | Residue |
| C | ARG253 |
| C | GLU255 |
| C | GLY256 |
| C | SER258 |
| C | ARG260 |
| C | HIS261 |
| C | ASN262 |
| C | PHE265 |
| C | MET267 |
| C | GLU366 |
| C | GLU370 |
| C | GLU411 |
| C | HIS412 |
| C | ASN414 |
| C | GLY467 |
| C | ARG470 |
| C | ILE481 |
| C | LYN495 |
| C | HOH507 |
| C | HOH509 |
| C | HOH723 |
| C | HOH819 |
| C | HOH915 |
| C | HOH917 |
| C | HOH925 |
| C | MG1200 |
| C | MG1201 |
| C | MG1202 |
| C | HOH1302 |
| C | HOH1303 |
| C | HOH1304 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LYN C 495 |
| Chain | Residue |
| C | GLY207 |
| C | ALA229 |
| C | GLU231 |
| C | ARG253 |
| C | MET267 |
| C | GLU269 |
| C | TYR271 |
| C | ASN414 |
| C | PHE416 |
| C | GLU418 |
| C | B4P494 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 1200 |
| Chain | Residue |
| C | GLU404 |
| C | GLU411 |
| C | ALA413 |
| C | ASN414 |
| C | B4P494 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 1201 |
| Chain | Residue |
| C | B4P494 |
| C | HOH509 |
| C | HOH819 |
| C | HOH915 |
| C | HOH917 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 1202 |
| Chain | Residue |
| C | GLU404 |
| C | GLU411 |
| C | B4P494 |
| C | HOH1302 |
| site_id | BC7 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE B4P D 494 |
| Chain | Residue |
| A | GLN438 |
| D | ARG253 |
| D | GLU255 |
| D | GLY256 |
| D | ARG260 |
| D | HIS261 |
| D | ASN262 |
| D | PHE265 |
| D | MET267 |
| D | GLU366 |
| D | GLU370 |
| D | GLU411 |
| D | HIS412 |
| D | ALA413 |
| D | ASN414 |
| D | GLY467 |
| D | ARG470 |
| D | ILE481 |
| D | LYN495 |
| D | HOH501 |
| D | HOH596 |
| D | HOH851 |
| D | HOH853 |
| D | HOH855 |
| D | HOH1164 |
| D | MG1300 |
| D | MG1301 |
| D | MG1302 |
| D | HOH1307 |
| site_id | BC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LYN D 495 |
| Chain | Residue |
| D | GLY207 |
| D | ALA208 |
| D | GLU231 |
| D | ARG253 |
| D | MET267 |
| D | GLU269 |
| D | TYR271 |
| D | ASN414 |
| D | PHE416 |
| D | GLU418 |
| D | B4P494 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 1300 |
| Chain | Residue |
| D | GLU404 |
| D | GLU411 |
| D | ALA413 |
| D | ASN414 |
| D | B4P494 |
| D | HOH1305 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 1301 |
| Chain | Residue |
| D | B4P494 |
| D | HOH596 |
| D | HOH851 |
| D | HOH852 |
| D | HOH853 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 1302 |
| Chain | Residue |
| D | GLU404 |
| D | GLU411 |
| D | B4P494 |
| D | HOH1307 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU404 | |
| A | GLU411 | |
| B | GLU404 | |
| B | GLU411 | |
| C | GLU404 | |
| C | GLU411 | |
| D | GLU404 | |
| D | GLU411 |
