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3A5Y

Crystal structure of GenX from Escherichia coli in complex with lysyladenylate analog

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0000166molecular_functionnucleotide binding
A0004812molecular_functionaminoacyl-tRNA ligase activity
A0004824molecular_functionlysine-tRNA ligase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006418biological_processtRNA aminoacylation for protein translation
A0006430biological_processlysyl-tRNA aminoacylation
A0016874molecular_functionligase activity
A0016880molecular_functionacid-ammonia (or amide) ligase activity
A0042803molecular_functionprotein homodimerization activity
A0043687biological_processpost-translational protein modification
A0052868molecular_functionprotein-lysine lysyltransferase activity
A0071468biological_processcellular response to acidic pH
B0000049molecular_functiontRNA binding
B0000166molecular_functionnucleotide binding
B0004812molecular_functionaminoacyl-tRNA ligase activity
B0004824molecular_functionlysine-tRNA ligase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006418biological_processtRNA aminoacylation for protein translation
B0006430biological_processlysyl-tRNA aminoacylation
B0016874molecular_functionligase activity
B0016880molecular_functionacid-ammonia (or amide) ligase activity
B0042803molecular_functionprotein homodimerization activity
B0043687biological_processpost-translational protein modification
B0052868molecular_functionprotein-lysine lysyltransferase activity
B0071468biological_processcellular response to acidic pH
C0000049molecular_functiontRNA binding
C0000166molecular_functionnucleotide binding
C0004812molecular_functionaminoacyl-tRNA ligase activity
C0004824molecular_functionlysine-tRNA ligase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006418biological_processtRNA aminoacylation for protein translation
C0006430biological_processlysyl-tRNA aminoacylation
C0016874molecular_functionligase activity
C0016880molecular_functionacid-ammonia (or amide) ligase activity
C0042803molecular_functionprotein homodimerization activity
C0043687biological_processpost-translational protein modification
C0052868molecular_functionprotein-lysine lysyltransferase activity
C0071468biological_processcellular response to acidic pH
D0000049molecular_functiontRNA binding
D0000166molecular_functionnucleotide binding
D0004812molecular_functionaminoacyl-tRNA ligase activity
D0004824molecular_functionlysine-tRNA ligase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006418biological_processtRNA aminoacylation for protein translation
D0006430biological_processlysyl-tRNA aminoacylation
D0016874molecular_functionligase activity
D0016880molecular_functionacid-ammonia (or amide) ligase activity
D0042803molecular_functionprotein homodimerization activity
D0043687biological_processpost-translational protein modification
D0052868molecular_functionprotein-lysine lysyltransferase activity
D0071468biological_processcellular response to acidic pH
Functional Information from PDB Data
site_idAC1
Number of Residues24
DetailsBINDING SITE FOR RESIDUE KAA A 1990
ChainResidue
ASER76
AGLU244
ALEU245
AALA246
AASN247
APHE249
AGLU251
AGLY296
AALA298
AGLY300
AARG303
AGLU78
ALEU314
AHOH394
AHOH409
AHOH478
AHOH563
AARG100
AGLU102
AHIS108
AASN109
APHE112
AMET114
ATYR118

site_idAC2
Number of Residues26
DetailsBINDING SITE FOR RESIDUE KAA B 1991
ChainResidue
BSER76
BGLU78
BARG100
BGLU102
BHIS108
BASN109
BPHE112
BMET114
BTYR118
BGLU244
BLEU245
BALA246
BASN247
BPHE249
BGLU251
BGLY296
BALA298
BGLY300
BARG303
BLEU314
BHOH399
BHOH404
BHOH428
BHOH429
BHOH495
BHOH553

site_idAC3
Number of Residues26
DetailsBINDING SITE FOR RESIDUE KAA C 1992
ChainResidue
CGLU78
CARG100
CGLU102
CHIS108
CASN109
CPHE112
CMET114
CTYR118
CGLU244
CLEU245
CALA246
CASN247
CPHE249
CGLU251
CGLY296
CALA298
CGLY300
CARG303
CLEU314
CHOH646
CHOH683
CHOH693
CHOH742
CHOH746
CHOH758
CHOH799

site_idAC4
Number of Residues26
DetailsBINDING SITE FOR RESIDUE KAA D 1993
ChainResidue
DHOH920
DHOH950
DHOH1001
DSER76
DGLU78
DARG100
DGLU102
DTYR107
DHIS108
DASN109
DPHE112
DMET114
DTYR118
DGLU244
DLEU245
DALA246
DASN247
DPHE249
DGLU251
DGLY296
DALA298
DGLY300
DARG303
DHOH867
DHOH905
DHOH916

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsBINDING:
ChainResidueDetails
ASER76
BASN109
BTYR118
BGLU244
BGLU251
BGLY300
CSER76
CARG100
CASN109
CTYR118
CGLU244
AARG100
CGLU251
CGLY300
DSER76
DARG100
DASN109
DTYR118
DGLU244
DGLU251
DGLY300
AASN109
ATYR118
AGLU244
AGLU251
AGLY300
BSER76
BARG100

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PDB entries from 2024-11-13

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