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3A29

Crystal structure of human liver FBPase in complex with tricyclic inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0006000biological_processfructose metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0006111biological_processregulation of gluconeogenesis
A0016208molecular_functionAMP binding
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030308biological_processnegative regulation of cell growth
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0031667biological_processresponse to nutrient levels
A0032869biological_processcellular response to insulin stimulus
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042578molecular_functionphosphoric ester hydrolase activity
A0042802molecular_functionidentical protein binding
A0045820biological_processnegative regulation of glycolytic process
A0046580biological_processnegative regulation of Ras protein signal transduction
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070062cellular_componentextracellular exosome
A0071286biological_processcellular response to magnesium ion
A0071320biological_processcellular response to cAMP
A0071466biological_processcellular response to xenobiotic stimulus
A0071475biological_processcellular hyperosmotic salinity response
A0071477biological_processcellular hypotonic salinity response
A0097403biological_processcellular response to raffinose
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0006000biological_processfructose metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0006111biological_processregulation of gluconeogenesis
B0016208molecular_functionAMP binding
B0016311biological_processdephosphorylation
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030308biological_processnegative regulation of cell growth
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0031667biological_processresponse to nutrient levels
B0032869biological_processcellular response to insulin stimulus
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042578molecular_functionphosphoric ester hydrolase activity
B0042802molecular_functionidentical protein binding
B0045820biological_processnegative regulation of glycolytic process
B0046580biological_processnegative regulation of Ras protein signal transduction
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070062cellular_componentextracellular exosome
B0071286biological_processcellular response to magnesium ion
B0071320biological_processcellular response to cAMP
B0071466biological_processcellular response to xenobiotic stimulus
B0071475biological_processcellular hyperosmotic salinity response
B0071477biological_processcellular hypotonic salinity response
B0097403biological_processcellular response to raffinose
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005975biological_processcarbohydrate metabolic process
C0006000biological_processfructose metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006094biological_processgluconeogenesis
C0006111biological_processregulation of gluconeogenesis
C0016208molecular_functionAMP binding
C0016311biological_processdephosphorylation
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030308biological_processnegative regulation of cell growth
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0031667biological_processresponse to nutrient levels
C0032869biological_processcellular response to insulin stimulus
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042578molecular_functionphosphoric ester hydrolase activity
C0042802molecular_functionidentical protein binding
C0045820biological_processnegative regulation of glycolytic process
C0046580biological_processnegative regulation of Ras protein signal transduction
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0070062cellular_componentextracellular exosome
C0071286biological_processcellular response to magnesium ion
C0071320biological_processcellular response to cAMP
C0071466biological_processcellular response to xenobiotic stimulus
C0071475biological_processcellular hyperosmotic salinity response
C0071477biological_processcellular hypotonic salinity response
C0097403biological_processcellular response to raffinose
C1904628biological_processcellular response to phorbol 13-acetate 12-myristate
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005975biological_processcarbohydrate metabolic process
D0006000biological_processfructose metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006094biological_processgluconeogenesis
D0006111biological_processregulation of gluconeogenesis
D0016208molecular_functionAMP binding
D0016311biological_processdephosphorylation
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030308biological_processnegative regulation of cell growth
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0031667biological_processresponse to nutrient levels
D0032869biological_processcellular response to insulin stimulus
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042578molecular_functionphosphoric ester hydrolase activity
D0042802molecular_functionidentical protein binding
D0045820biological_processnegative regulation of glycolytic process
D0046580biological_processnegative regulation of Ras protein signal transduction
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0070062cellular_componentextracellular exosome
D0071286biological_processcellular response to magnesium ion
D0071320biological_processcellular response to cAMP
D0071466biological_processcellular response to xenobiotic stimulus
D0071475biological_processcellular hyperosmotic salinity response
D0071477biological_processcellular hypotonic salinity response
D0097403biological_processcellular response to raffinose
D1904628biological_processcellular response to phorbol 13-acetate 12-myristate
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 2T0 A 401
ChainResidue
AVAL17
ATHR31
ALYS112
ATYR113
AARG140
AHOH361
AHOH375
AGLU20
AGLY21
AALA24
AGLY26
ATHR27
AGLY28
AGLU29
ALEU30

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 2T0 B 401
ChainResidue
BVAL17
BGLU20
BGLY21
BALA24
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BLYS112
BTYR113
BARG140
BMET177
BHOH354
BHOH410

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 2T0 C 401
ChainResidue
CVAL17
CGLU20
CGLY21
CALA24
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CLYS112
CTYR113
CMET177
CHOH350
CHOH418
CHOH434
CHOH435

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 2T0 D 401
ChainResidue
DVAL17
DGLU20
DGLY21
DALA24
DGLY26
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DLYS112
DTYR113
DARG140
DMET177
DHOH339
DHOH375

Functional Information from PROSITE/UniProt
site_idPS00124
Number of Residues13
DetailsFBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA
ChainResidueDetails
AGLY273-ALA285

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:7809062, ECO:0007744|PDB:1FTA
ChainResidueDetails
AVAL17
CTHR27
CLYS112
CARG140
DVAL17
DTHR27
DLYS112
DARG140
ATHR27
ALYS112
AARG140
BVAL17
BTHR27
BLYS112
BARG140
CVAL17

site_idSWS_FT_FI2
Number of Residues28
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00636
ChainResidueDetails
AASP68
BLEU120
BASN212
BARG243
BTYR264
BLYS274
CASP68
CGLU97
CLEU120
CASN212
CARG243
AGLU97
CTYR264
CLYS274
DASP68
DGLU97
DLEU120
DASN212
DARG243
DTYR264
DLYS274
ALEU120
AASN212
AARG243
ATYR264
ALYS274
BASP68
BGLU97

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0007744|PDB:2FHY
ChainResidueDetails
AASP118
DASP118
DASP121
DGLU280
AASP121
AGLU280
BASP118
BASP121
BGLU280
CASP118
CASP121
CGLU280

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P00637
ChainResidueDetails
AALA1
BALA1
CALA1
DALA1

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
ALYS150
BLYS150
CLYS150
DLYS150

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
ATYR215
ATYR244
BTYR215
BTYR244
CTYR215
CTYR244
DTYR215
DTYR244

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATYR264
BTYR264
CTYR264
DTYR264

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eyi
ChainResidueDetails
AGLU98
AASP74

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eyi
ChainResidueDetails
BGLU98
BASP74

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eyi
ChainResidueDetails
CGLU98
CASP74

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1eyi
ChainResidueDetails
DGLU98
DASP74

227344

PDB entries from 2024-11-13

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