30UC
Complex of transglutaminase 2 and the 45 kDa domain of fibronectin
Functional Information from PROSITE/UniProt
| site_id | PS00023 |
| Number of Residues | 42 |
| Details | FN2_1 Fibronectin type-II collagen-binding domain signature. CvlPFtYngrtfysCttegrqdghlWCsttsNYeqdqkYsFC |
| Chain | Residue | Details |
| B | CYS360-CYS401 | |
| B | CYS420-CYS461 |
| site_id | PS00547 |
| Number of Residues | 18 |
| Details | TRANSGLUTAMINASES Transglutaminases active site. GQCWVfAAVacTvLRCLG |
| Chain | Residue | Details |
| A | GLY275-GLY292 |
| site_id | PS01253 |
| Number of Residues | 35 |
| Details | FN1_1 Fibronectin type-I domain signature. Cvtdsgvv.YsvgmqWlKtqgnkqml..CtClgngvs...C |
| Chain | Residue | Details |
| B | CYS308-CYS342 | |
| B | CYS470-CYS508 | |
| B | CYS518-CYS555 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10024","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7649299","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8943303","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10024","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00488","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31991788","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25192068","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30321187","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31991788","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11867708","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20450932","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1KV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PYG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6KZB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"UniProtKB","id":"P52181","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)","evidences":[{"source":"UniProtKB","id":"P08587","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 43 |
| Details | Domain: {"description":"Fibronectin type-I 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00478","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 42 |
| Details | Domain: {"description":"Fibronectin type-I 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00478","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 13 |
| Details | Region: {"description":"Critical for collagen binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16037490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16037490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
