2ZZ5
Orotidine Monophosphate Deacarboxylase D70A/K72A double mutant from M. thermoautotrophicum complexed with 6- cyano-UMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 6CN A 301 |
Chain | Residue |
A | ASP20 |
A | HOH402 |
A | HOH403 |
A | HOH407 |
A | HOH408 |
B | ASP75 |
B | ILE76 |
B | THR79 |
B | HOH465 |
A | LYS42 |
A | ILE96 |
A | MET126 |
A | SER127 |
A | PRO180 |
A | GLN185 |
A | GLY202 |
A | ARG203 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE 6CN B 302 |
Chain | Residue |
A | ASP75 |
A | ILE76 |
A | THR79 |
A | HOH466 |
B | ASP20 |
B | LYS42 |
B | ILE96 |
B | MET126 |
B | SER127 |
B | PRO180 |
B | GLN185 |
B | GLY202 |
B | ARG203 |
B | HOH422 |
B | HOH423 |
B | HOH426 |
B | HOH427 |
B | HOH428 |
B | HOH431 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | ALA72 | |
B | ALA72 |
site_id | SWS_FT_FI2 |
Number of Residues | 14 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP20 | |
B | ALA70 | |
B | SER127 | |
B | PRO180 | |
B | GLY202 | |
B | ARG203 | |
A | LYS42 | |
A | ALA70 | |
A | SER127 | |
A | PRO180 | |
A | GLY202 | |
A | ARG203 | |
B | ASP20 | |
B | LYS42 |