2ZYL
Crystal structure of 3-ketosteroid-9-alpha-hydroxylase (KshA) from M. tuberculosis
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0006694 | biological_process | steroid biosynthetic process |
A | 0006707 | biological_process | cholesterol catabolic process |
A | 0008203 | biological_process | cholesterol metabolic process |
A | 0016042 | biological_process | lipid catabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0036200 | molecular_function | 3-ketosteroid 9-alpha-monooxygenase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0047086 | molecular_function | ketosteroid monooxygenase activity |
A | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
A | 0070207 | biological_process | protein homotrimerization |
A | 0070723 | biological_process | response to cholesterol |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE FES A 451 |
Chain | Residue |
A | CYS67 |
A | HIS69 |
A | MET70 |
A | GLY72 |
A | CYS86 |
A | PHE88 |
A | HIS89 |
A | TRP91 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE FE2 A 452 |
Chain | Residue |
A | HIS186 |
A | ASP304 |
A | HOH561 |
A | HIS181 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 387 |
Chain | Residue |
A | THR177 |
A | ASP178 |
A | MET179 |
A | GLU322 |
A | ASP323 |
A | HOH435 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00628, ECO:0000269|PubMed:19234303, ECO:0000269|PubMed:25049233 |
Chain | Residue | Details |
A | CYS67 | |
A | HIS69 | |
A | CYS86 | |
A | HIS89 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:F1CMY8 |
Chain | Residue | Details |
A | ASN175 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19234303, ECO:0000269|PubMed:25049233 |
Chain | Residue | Details |
A | HIS181 | |
A | HIS186 | |
A | ASP304 |