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2ZYD

Dimeric 6-phosphogluconate dehydrogenase complexed with glucose

Functional Information from GO Data
ChainGOidnamespacecontents
A0004616molecular_functionphosphogluconate dehydrogenase (decarboxylating) activity
A0005829cellular_componentcytosol
A0006098biological_processpentose-phosphate shunt
A0009051biological_processpentose-phosphate shunt, oxidative branch
A0016054biological_processorganic acid catabolic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019521biological_processD-gluconate metabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0046177biological_processD-gluconate catabolic process
A0050661molecular_functionNADP binding
A0097216molecular_functionguanosine tetraphosphate binding
B0004616molecular_functionphosphogluconate dehydrogenase (decarboxylating) activity
B0005829cellular_componentcytosol
B0006098biological_processpentose-phosphate shunt
B0009051biological_processpentose-phosphate shunt, oxidative branch
B0016054biological_processorganic acid catabolic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0019521biological_processD-gluconate metabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0046177biological_processD-gluconate catabolic process
B0050661molecular_functionNADP binding
B0097216molecular_functionguanosine tetraphosphate binding
Functional Information from PROSITE/UniProt
site_idPS00461
Number of Residues13
Details6PGD 6-phosphogluconate dehydrogenase signature. IlDeaANKGTGkW
ChainResidueDetails
AILE253-TRP265

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000269|PubMed:19686854
ChainResidueDetails
ALYS183
BLYS183

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:19686854
ChainResidueDetails
AGLU190
BGLU190

site_idSWS_FT_FI3
Number of Residues10
DetailsBINDING:
ChainResidueDetails
AGLY10
BHIS451
AASN33
AVAL74
AARG445
AHIS451
BGLY10
BASN33
BVAL74
BARG445

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: in other chain
ChainResidueDetails
AASN102
ASER128
ALYS260
AARG287
BASN102
BSER128
BLYS260
BARG287

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: in other chain => ECO:0000250
ChainResidueDetails
AHIS186
ATYR191
BHIS186
BTYR191

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 2pgd
ChainResidueDetails
AASN187
ALYS183
AGLY130
AGLU190

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 2pgd
ChainResidueDetails
BASN187
BLYS183
BGLY130
BGLU190

227933

PDB entries from 2024-11-27

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