2ZYA
Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019521 | biological_process | D-gluconate metabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0097216 | molecular_function | guanosine tetraphosphate binding |
| B | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006098 | biological_process | pentose-phosphate shunt |
| B | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019521 | biological_process | D-gluconate metabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0097216 | molecular_function | guanosine tetraphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 6PG A2002 |
| Chain | Residue |
| A | ASN102 |
| A | ASN259 |
| A | LYS260 |
| A | ARG287 |
| A | ILE365 |
| A | HOH656 |
| A | HOH657 |
| A | HOH714 |
| A | HOH946 |
| B | ARG445 |
| B | PHE448 |
| A | SER128 |
| B | HIS451 |
| A | GLY129 |
| A | GLY130 |
| A | LYS183 |
| A | HIS186 |
| A | ASN187 |
| A | GLU190 |
| A | TYR191 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 6PG B2001 |
| Chain | Residue |
| A | ARG445 |
| A | PHE448 |
| A | HIS451 |
| B | ASN102 |
| B | SER128 |
| B | GLY129 |
| B | GLY130 |
| B | LYS183 |
| B | HIS186 |
| B | ASN187 |
| B | GLU190 |
| B | TYR191 |
| B | LYS260 |
| B | ARG287 |
| B | ILE365 |
| B | HOH661 |
| B | HOH839 |
| B | HOH915 |
| B | HOH928 |
| B | HOH1264 |
Functional Information from PROSITE/UniProt
| site_id | PS00461 |
| Number of Residues | 13 |
| Details | 6PGD 6-phosphogluconate dehydrogenase signature. IlDeaANKGTGkW |
| Chain | Residue | Details |
| A | ILE253-TRP265 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"19686854","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"19686854","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"description":"in other chain"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in other chain","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 2pgd |
| Chain | Residue | Details |
| A | ASN187 | |
| A | LYS183 | |
| A | GLY130 | |
| A | GLU190 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 2pgd |
| Chain | Residue | Details |
| B | ASN187 | |
| B | LYS183 | |
| B | GLY130 | |
| B | GLU190 |
