2ZWS
Crystal Structure Analysis of neutral ceramidase from Pseudomonas aeruginosa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017040 | molecular_function | N-acylsphingosine amidohydrolase activity |
| A | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
| A | 0046512 | biological_process | sphingosine biosynthetic process |
| A | 0046514 | biological_process | ceramide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051872 | biological_process | sphingosine catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 647 |
| Chain | Residue |
| A | HIS97 |
| A | HIS204 |
| A | GLU411 |
| A | TYR448 |
| A | HOH966 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 648 |
| Chain | Residue |
| A | HOH711 |
| A | HIS37 |
| A | ASP579 |
| A | ASP581 |
| A | THR584 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A 649 |
| Chain | Residue |
| A | PHE67 |
| A | GLN68 |
| A | SER106 |
| A | TYR108 |
| A | ALA444 |
| A | TYR445 |
| A | HOH671 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FMT A 650 |
| Chain | Residue |
| A | ARG43 |
| A | ASN60 |
| A | ASP62 |
| A | THR96 |
| A | LYS220 |
| A | SER224 |
| A | ALA240 |
| A | PHE241 |
| A | HOH703 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 651 |
| Chain | Residue |
| A | ASP500 |
| A | CYS503 |
| A | THR510 |
| A | GLY511 |
| A | VAL512 |
| A | HOH1091 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PLM A 652 |
| Chain | Residue |
| A | ARG298 |
| A | ARG489 |
| A | LEU490 |
| A | PRO491 |
| A | VAL492 |
| A | GLU493 |
| A | ILE519 |
| A | HOH782 |
| A | HOH1261 |
| A | HOH1282 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 653 |
| Chain | Residue |
| A | ASP2 |
| A | LEU3 |
| A | ALA50 |
| A | HOH1061 |
| A | HOH1156 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 654 |
| Chain | Residue |
| A | ARG6 |
| A | GLU48 |
| A | LEU141 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 655 |
| Chain | Residue |
| A | HIS107 |
| A | ALA109 |
| A | PHE351 |
| A | CYS504 |
| A | MET506 |
| A | HOH686 |
| A | HOH855 |
| A | HOH1110 |
| A | HOH1243 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 656 |
| Chain | Residue |
| A | MET24 |
| A | GLY25 |
| A | TYR445 |
| A | TYR448 |
| A | TYR460 |
| A | HOH966 |
| A | HOH1173 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 657 |
| Chain | Residue |
| A | GLU152 |
| A | LEU153 |
| A | ARG154 |
| A | ASN155 |
| A | LYS279 |
| A | HOH920 |
| A | HOH937 |
| A | HOH1232 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 658 |
| Chain | Residue |
| A | ARG158 |
| A | THR206 |
| A | SER250 |
| A | PRO251 |
| A | HOH866 |
| A | HOH975 |
| A | HOH1169 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 659 |
| Chain | Residue |
| A | HIS37 |
| A | TRP582 |
| A | ASP583 |
| A | GLN585 |
| A | SER603 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 660 |
| Chain | Residue |
| A | GLY84 |
| A | VAL85 |
| A | ASP87 |
| A | ASN90 |
| A | HOH908 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 661 |
| Chain | Residue |
| A | SER27 |
| A | GOL664 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 662 |
| Chain | Residue |
| A | HOH1177 |
| A | TYR222 |
| A | TYR225 |
| A | ASP230 |
| A | ARG270 |
| A | ASP583 |
| A | PRO605 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 663 |
| Chain | Residue |
| A | TYR614 |
| A | ARG616 |
| A | GLY634 |
| A | SER635 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 664 |
| Chain | Residue |
| A | GLU345 |
| A | LEU358 |
| A | GOL661 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 665 |
| Chain | Residue |
| A | LYS32 |
| A | ALA34 |
| A | HIS213 |
| A | ARG587 |
| A | HOH790 |
| A | HOH817 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 666 |
| Chain | Residue |
| A | LEU166 |
| A | GLU271 |
| A | LEU274 |
| A | HOH892 |
| A | HOH992 |
| A | HOH1065 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 667 |
| Chain | Residue |
| A | ASN155 |
| A | GLY192 |
| A | LEU194 |
| A | ASN252 |
| A | LEU253 |
| A | GOL668 |
| A | HOH857 |
| A | HOH962 |
| site_id | CC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 668 |
| Chain | Residue |
| A | ASN155 |
| A | GLY192 |
| A | ASN252 |
| A | ALA284 |
| A | GOL667 |
| A | HOH767 |
| A | HOH800 |
| A | HOH857 |
| A | HOH962 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 669 |
| Chain | Residue |
| A | GLU20 |
| A | LYS32 |
| A | GLN509 |
| A | HOH968 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19088069","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ZWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZXC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19088069","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
