2ZW7
Crystal structure of bleomycin N-acetyltransferase complexed with bleomycin A2 and coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008999 | molecular_function | peptide-alanine-alpha-N-acetyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0017198 | biological_process | obsolete N-terminal peptidyl-serine acetylation |
| A | 1990189 | molecular_function | peptide-serine-alpha-N-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008999 | molecular_function | peptide-alanine-alpha-N-acetyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0017198 | biological_process | obsolete N-terminal peptidyl-serine acetylation |
| B | 1990189 | molecular_function | peptide-serine-alpha-N-acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE COA A 401 |
| Chain | Residue |
| A | ARG16 |
| A | TYR108 |
| A | ALA109 |
| A | THR110 |
| A | ASN137 |
| A | ARG139 |
| A | SER140 |
| A | VAL143 |
| A | ARG146 |
| A | BLM402 |
| A | VAL40 |
| A | TRP97 |
| A | LEU98 |
| A | LEU99 |
| A | TRP104 |
| A | GLY105 |
| A | HIS106 |
| A | GLY107 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE BLM A 402 |
| Chain | Residue |
| A | THR45 |
| A | ALA64 |
| A | LEU87 |
| A | GLY88 |
| A | THR90 |
| A | GLY94 |
| A | LEU95 |
| A | THR96 |
| A | TRP132 |
| A | GLN157 |
| A | HIS158 |
| A | TYR159 |
| A | TRP280 |
| A | COA401 |
| B | PHE219 |
| B | SER228 |
| B | ARG234 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE BLM B 403 |
| Chain | Residue |
| A | ILE213 |
| A | PHE219 |
| A | SER228 |
| A | ARG234 |
| B | TRP44 |
| B | THR45 |
| B | LEU87 |
| B | GLY88 |
| B | THR90 |
| B | GLY94 |
| B | THR96 |
| B | TRP132 |
| B | GLN157 |
| B | HIS158 |
| B | ARG277 |
| B | TRP280 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GPHEMVVLGKA |
| Chain | Residue | Details |
| A | GLY164-ALA174 |
