2ZW4

Crystal structure of bleomycin N-acetyltransferase complexed with coenzyme A in the orthorhombic crystal

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0008999	molecular_function	peptide-alanine-alpha-N-acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	1990189	molecular_function	peptide-serine-alpha-N-acetyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0008999	molecular_function	peptide-alanine-alpha-N-acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	1990189	molecular_function	peptide-serine-alpha-N-acetyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0008999	molecular_function	peptide-alanine-alpha-N-acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	1990189	molecular_function	peptide-serine-alpha-N-acetyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0008999	molecular_function	peptide-alanine-alpha-N-acetyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	1990189	molecular_function	peptide-serine-alpha-N-acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE COA A 401

Chain	Residue
A	ARG16
A	GLY107
A	TYR108
A	ALA109
A	THR110
A	ASN137
A	ARG139
A	SER140
A	ARG146
A	HOH424
A	HOH548
A	VAL40
C	COA402
A	TRP43
A	TRP44
A	TRP97
A	LEU99
A	TRP104
A	GLY105
A	HIS106

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 405

Chain	Residue
A	ARG29
A	PRO52
B	ARG199
B	HOH444

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 406

Chain	Residue
A	GLU54
A	ARG57
C	ARG46
C	TYR58

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 403

Chain	Residue
B	GLY105
B	HIS106
B	GLY107
B	TYR108
B	ALA109
B	ARG139
C	GLU18

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 407

Chain	Residue
A	VAL185
B	ALA184
B	VAL185
B	HOH570

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE COA C 402

Chain	Residue
A	COA401
C	ARG16
C	VAL40
C	TRP44
C	TRP97
C	LEU98
C	LEU99
C	TRP104
C	GLY105
C	HIS106
C	GLY107
C	TYR108
C	ALA109
C	THR110
C	ASN137
C	ARG139
C	SER140
C	VAL143
C	ARG146
C	HOH420

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 404

Chain	Residue
D	GLY107
D	TYR108
D	ALA109
D	THR110
D	VAL143
D	ARG146

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 408

Chain	Residue
C	ALA184
C	VAL185
D	ALA184
D	VAL185
D	HOH438
D	HOH620
D	HOH633

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 409

Chain	Residue
D	PRO66
D	GLY67
D	ARG69

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 410

Chain	Residue
D	THR96
D	TRP97
D	TRP132
D	ILE133
D	SER140

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 411

Chain	Residue
C	ARG278
D	HIS33
D	ARG100
D	ARG101
D	ASP102

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Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GPHEMVVLGKA

Chain	Residue	Details
A	GLY164-ALA174

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