Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2ZVW

Crystal structure of Proliferating cell nuclear antigen 2 and Short peptide from human P21

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006275	biological_process	regulation of DNA replication
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0042276	biological_process	error-prone translesion synthesis
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006275	biological_process	regulation of DNA replication
B	0030337	molecular_function	DNA polymerase processivity factor activity
B	0042276	biological_process	error-prone translesion synthesis
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006275	biological_process	regulation of DNA replication
C	0030337	molecular_function	DNA polymerase processivity factor activity
C	0042276	biological_process	error-prone translesion synthesis
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006275	biological_process	regulation of DNA replication
D	0030337	molecular_function	DNA polymerase processivity factor activity
D	0042276	biological_process	error-prone translesion synthesis
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006275	biological_process	regulation of DNA replication
E	0030337	molecular_function	DNA polymerase processivity factor activity
E	0042276	biological_process	error-prone translesion synthesis
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006275	biological_process	regulation of DNA replication
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0042276	biological_process	error-prone translesion synthesis
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0006275	biological_process	regulation of DNA replication
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0042276	biological_process	error-prone translesion synthesis
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005829	cellular_component	cytosol
H	0006260	biological_process	DNA replication
H	0006275	biological_process	regulation of DNA replication
H	0030337	molecular_function	DNA polymerase processivity factor activity
H	0042276	biological_process	error-prone translesion synthesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 901

Chain	Residue
A	ALA208
A	ARG210
A	LYS254

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 911

Chain	Residue
B	ASP156
B	ALA208
B	ARG210
B	LYS254
B	HOH1266

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 921

Chain	Residue
C	ALA208
C	ARG210
C	LYS254
C	ASP156

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 931

Chain	Residue
D	ARG210
D	LYS254

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 941

Chain	Residue
E	ARG210
E	HOH1304

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 951

Chain	Residue
F	ARG210
F	LYS254

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 961

Chain	Residue
H	ARG210
H	LYS254

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlsMgmnLgNMsKML

Chain	Residue	Details
A	ARG61-LEU79

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GFsLqAMDsSHVaLVsLlLrsegF

Chain	Residue	Details
A	GLY34-PHE57

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269\|PubMed:10753973, ECO:0000269\|PubMed:11463845, ECO:0000269\|PubMed:12431783, ECO:0000269\|PubMed:16982699, ECO:0000269\|PubMed:20307683

Chain	Residue	Details
I	THR145
J	THR145
K	THR145
L	THR145
M	THR145
N	THR145
O	THR145
P	THR145

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC and NUAK1 => ECO:0000269\|PubMed:10753973, ECO:0000269\|PubMed:25329316

Chain	Residue	Details
I	SER146
J	SER146
K	SER146
L	SER146
M	SER146
N	SER146
O	SER146
P	SER146

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC; in vitro => ECO:0000269\|PubMed:10753973

Chain	Residue	Details
I	SER160
J	SER160
K	SER160
L	SER160
M	SER160
N	SER160
O	SER160
P	SER160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)