Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2ZVW

Crystal structure of Proliferating cell nuclear antigen 2 and Short peptide from human P21

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006272	biological_process	leading strand elongation
A	0006275	biological_process	regulation of DNA replication
A	0006298	biological_process	mismatch repair
A	0019985	biological_process	translesion synthesis
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0042276	biological_process	error-prone translesion synthesis
A	0043626	cellular_component	PCNA complex
B	0003677	molecular_function	DNA binding
B	0005634	cellular_component	nucleus
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006272	biological_process	leading strand elongation
B	0006275	biological_process	regulation of DNA replication
B	0006298	biological_process	mismatch repair
B	0019985	biological_process	translesion synthesis
B	0030337	molecular_function	DNA polymerase processivity factor activity
B	0042276	biological_process	error-prone translesion synthesis
B	0043626	cellular_component	PCNA complex
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006272	biological_process	leading strand elongation
C	0006275	biological_process	regulation of DNA replication
C	0006298	biological_process	mismatch repair
C	0019985	biological_process	translesion synthesis
C	0030337	molecular_function	DNA polymerase processivity factor activity
C	0042276	biological_process	error-prone translesion synthesis
C	0043626	cellular_component	PCNA complex
D	0003677	molecular_function	DNA binding
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006272	biological_process	leading strand elongation
D	0006275	biological_process	regulation of DNA replication
D	0006298	biological_process	mismatch repair
D	0019985	biological_process	translesion synthesis
D	0030337	molecular_function	DNA polymerase processivity factor activity
D	0042276	biological_process	error-prone translesion synthesis
D	0043626	cellular_component	PCNA complex
E	0003677	molecular_function	DNA binding
E	0005634	cellular_component	nucleus
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006272	biological_process	leading strand elongation
E	0006275	biological_process	regulation of DNA replication
E	0006298	biological_process	mismatch repair
E	0019985	biological_process	translesion synthesis
E	0030337	molecular_function	DNA polymerase processivity factor activity
E	0042276	biological_process	error-prone translesion synthesis
E	0043626	cellular_component	PCNA complex
F	0003677	molecular_function	DNA binding
F	0005634	cellular_component	nucleus
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006272	biological_process	leading strand elongation
F	0006275	biological_process	regulation of DNA replication
F	0006298	biological_process	mismatch repair
F	0019985	biological_process	translesion synthesis
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0042276	biological_process	error-prone translesion synthesis
F	0043626	cellular_component	PCNA complex
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0006272	biological_process	leading strand elongation
G	0006275	biological_process	regulation of DNA replication
G	0006298	biological_process	mismatch repair
G	0019985	biological_process	translesion synthesis
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0042276	biological_process	error-prone translesion synthesis
G	0043626	cellular_component	PCNA complex
H	0003677	molecular_function	DNA binding
H	0005634	cellular_component	nucleus
H	0005829	cellular_component	cytosol
H	0006260	biological_process	DNA replication
H	0006272	biological_process	leading strand elongation
H	0006275	biological_process	regulation of DNA replication
H	0006298	biological_process	mismatch repair
H	0019985	biological_process	translesion synthesis
H	0030337	molecular_function	DNA polymerase processivity factor activity
H	0042276	biological_process	error-prone translesion synthesis
H	0043626	cellular_component	PCNA complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 901

Chain	Residue
A	ALA208
A	ARG210
A	LYS254

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 911

Chain	Residue
B	ASP156
B	ALA208
B	ARG210
B	LYS254
B	HOH1266

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 921

Chain	Residue
C	ALA208
C	ARG210
C	LYS254
C	ASP156

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 931

Chain	Residue
D	ARG210
D	LYS254

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 941

Chain	Residue
E	ARG210
E	HOH1304

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 951

Chain	Residue
F	ARG210
F	LYS254

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 961

Chain	Residue
H	ARG210
H	LYS254

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlsMgmnLgNMsKML

Chain	Residue	Details
A	ARG61-LEU79

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GFsLqAMDsSHVaLVsLlLrsegF

Chain	Residue	Details
A	GLY34-PHE57

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	152
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2","evidences":[{"source":"PubMed","id":"10753973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11463845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12431783","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16982699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20307683","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by PKC and NUAK1","evidences":[{"source":"PubMed","id":"10753973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25329316","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)