2ZU3

Complex structure of CVB3 3C protease with TG-0204998

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ZU3 A 501

Chain	Residue
A	HIS40
A	CYS147
A	HIS161
A	VAL162
A	GLY163
A	GLY164
A	ASN165
A	HOH317
A	HOH389
A	HOH402
A	GLU71
A	ASN126
A	LEU127
A	GLY128
A	THR142
A	ARG143
A	ALA144
A	GLY145

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: For protease 3C activity => ECO:0000255|PROSITE-ProRule:PRU01222

Chain	Residue	Details
A	HIS40
A	GLU71

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: For protease 3C activity => ECO:0000269|PubMed:33691586

Chain	Residue	Details
A	CYS147

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by protease 3C => ECO:0000250|UniProtKB:P03301

Chain	Residue	Details
A	GLN183

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1cqq

Chain	Residue	Details
A	GLY145
A	HIS40
A	GLU71
A	CYS147

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