Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2ZRS

Crystal structure of Ca2+-bound form of des3-23ALG-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding
C	0005509	molecular_function	calcium ion binding
D	0005509	molecular_function	calcium ion binding
E	0005509	molecular_function	calcium ion binding
F	0005509	molecular_function	calcium ion binding
G	0005509	molecular_function	calcium ion binding
H	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 990

Chain	Residue
A	ASP103
A	ARG104
A	ASP105
A	MET109
A	GLU114

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 991

Chain	Residue
A	SER40
A	GLY41
A	GLU47

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 990

Chain	Residue
B	ASP105
B	ASN106
B	SER107
B	MET109
B	GLU114
B	ASP103

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 991

Chain	Residue
B	ASP169
B	THR170
B	ASP171
B	TRP175

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 992

Chain	Residue
B	ASP36
B	ASP38
B	SER40
B	SER44
B	GLU47

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 990

Chain	Residue
C	ASP36
C	ASP38
C	GLU47

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 991

Chain	Residue
C	ASP105
C	SER107
C	MET109

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 992

Chain	Residue
C	ASP169
C	ASP173
C	TRP175

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 990

Chain	Residue
D	ASP36
D	ASP38
D	SER40
D	SER44
D	GLU47

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 991

Chain	Residue
D	ASP103
D	ASP105
D	SER107
D	MET109
D	GLU114

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 992

Chain	Residue
D	ASP169
D	ASP171
D	ASP173
D	ILE176

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 990

Chain	Residue
E	ASP36
E	ASP38
E	SER40
E	GLU47

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 991

Chain	Residue
E	ASP103
E	ASP105
E	SER107
E	MET109
E	ILE110
E	GLU114

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 992

Chain	Residue
E	ASP169
E	ASP173
E	TRP175
E	ILE176

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA F 990

Chain	Residue
F	ASP36
F	SER40
F	GLU47

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 991

Chain	Residue
F	ASP103
F	ASP105
F	SER107
F	MET109
F	GLU114

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 992

Chain	Residue
F	ASP169
F	ASP171
F	ASP173
F	TRP175
F	ILE176

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA G 990

Chain	Residue
G	ASP36
G	ASP38
G	SER40
G	GLU47

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 991

Chain	Residue
G	ASP103
G	ASP105
G	SER107
G	GLY108
G	MET109
G	GLU114

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA G 992

Chain	Residue
G	TRP175
G	ILE176

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA H 990

Chain	Residue
H	ASP36
H	SER40
H	GLU47

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA H 991

Chain	Residue
H	ASP103
H	SER107
H	GLY108
H	MET109

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 992

Chain	Residue
H	TYR168
H	ASP169
H	THR170
H	ASP173
H	TRP175

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA G 1

Chain	Residue
F	ASN106
G	ASN106

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 2

Chain	Residue
B	ASN106
C	ASN106

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDRSGVISdtEL

Chain	Residue	Details
A	ASP36-LEU48
A	ASP103-LEU115

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448, ECO:0000269\|PubMed:18940611, ECO:0000269\|PubMed:18997320, ECO:0000269\|PubMed:20691033, ECO:0000269\|PubMed:25667979

Chain	Residue	Details
A	ASP36
B	ASP36
B	ASP38
B	SER40
B	GLU47
B	ASP103
B	ASP105
B	SER107
B	MET109
B	GLU114
C	ASP36
A	ASP38
C	ASP38
C	SER40
C	GLU47
C	ASP103
C	ASP105
C	SER107
C	MET109
C	GLU114
D	ASP36
D	ASP38
A	SER40
D	SER40
D	GLU47
D	ASP103
D	ASP105
D	SER107
D	MET109
D	GLU114
E	ASP36
E	ASP38
E	SER40
A	GLU47
E	GLU47
E	ASP103
E	ASP105
E	SER107
E	MET109
E	GLU114
F	ASP36
F	ASP38
F	SER40
F	GLU47
A	ASP103
F	ASP103
F	ASP105
F	SER107
F	MET109
F	GLU114
G	ASP36
G	ASP38
G	SER40
G	GLU47
G	ASP103
A	ASP105
G	ASP105
G	SER107
G	MET109
G	GLU114
H	ASP36
H	ASP38
H	SER40
H	GLU47
H	ASP103
H	ASP105
A	SER107
H	SER107
H	MET109
H	GLU114
A	MET109
A	GLU114

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:18940611, ECO:0000269\|PubMed:18997320, ECO:0000269\|PubMed:20691033, ECO:0000269\|PubMed:25667979

Chain	Residue	Details
A	VAL42
B	VAL42
C	VAL42
D	VAL42
E	VAL42
F	VAL42
G	VAL42
H	VAL42

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P12815

Chain	Residue	Details
A	ASP169
C	ASP171
C	ASP173
C	TRP175
D	ASP169
D	ASP171
D	ASP173
D	TRP175
E	ASP169
E	ASP171
E	ASP173
A	ASP171
E	TRP175
F	ASP169
F	ASP171
F	ASP173
F	TRP175
G	ASP169
G	ASP171
G	ASP173
G	TRP175
H	ASP169
A	ASP173
H	ASP171
H	ASP173
H	TRP175
A	TRP175
B	ASP169
B	ASP171
B	ASP173
B	TRP175
C	ASP169

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)