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2ZND

Crystal structure of Ca2+-free form of des3-20ALG-2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001525biological_processangiogenesis
A0001938biological_processpositive regulation of endothelial cell proliferation
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
A0006915biological_processapoptotic process
A0010595biological_processpositive regulation of endothelial cell migration
A0012507cellular_componentER to Golgi transport vesicle membrane
A0014029biological_processneural crest formation
A0014032biological_processneural crest cell development
A0016020cellular_componentmembrane
A0030127cellular_componentCOPII vesicle coat
A0030674molecular_functionprotein-macromolecule adaptor activity
A0030948biological_processnegative regulation of vascular endothelial growth factor receptor signaling pathway
A0031410cellular_componentcytoplasmic vesicle
A0031463cellular_componentCul3-RING ubiquitin ligase complex
A0032007biological_processnegative regulation of TOR signaling
A0034605biological_processcellular response to heat
A0036324biological_processvascular endothelial growth factor receptor-2 signaling pathway
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043280biological_processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043495molecular_functionprotein-membrane adaptor activity
A0045766biological_processpositive regulation of angiogenesis
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0046983molecular_functionprotein dimerization activity
A0048208biological_processCOPII vesicle coating
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051592biological_processresponse to calcium ion
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070062cellular_componentextracellular exosome
A0070971cellular_componentendoplasmic reticulum exit site
A0097190biological_processapoptotic signaling pathway
A1902527biological_processpositive regulation of protein monoubiquitination
A1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MRD A 1
ChainResidue
AARG66
ASER70
AASP73
AASN76
ALYS77
AALA78
AHOH307

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MRD A 2
ChainResidue
AGLY55
AGLN96
AARG100
APHE148
ASER53
AASN54

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MRD A 3
ChainResidue
ATHR162
AASP169
AGLY174
AHOH205
AHOH234

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MRD A 4
ChainResidue
AMRD5
AASP94
ATRP95
AVAL98

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MRD A 5
ChainResidue
AMRD4
AARG104
APHE122
ATYR124
AGLN159
AHOH207

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO4 A 192
ChainResidue
AARG140
AGLN141

site_idAC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO4 A 193
ChainResidue
APHE188
AHOH280

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 194
ChainResidue
AASP36
AASP38
ASER40
AVAL42
AGLU47
AHOH268

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA A 195
ChainResidue
AASP103
AASP105
ASER107
AMET109
AHOH221

site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 196
ChainResidue
AASP169
AASP171
AASP173
ATRP175
AHOH223
AHOH252

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDRSGVISdtEL
ChainResidueDetails
AASP36-LEU48
AASP103-LEU115

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:18940611, ECO:0000269|PubMed:18997320, ECO:0000269|PubMed:20691033, ECO:0000269|PubMed:25667979
ChainResidueDetails
AASP36
AASP38
ASER40
AGLU47
AASP103
AASP105
ASER107
AMET109
AGLU114

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:18940611, ECO:0000269|PubMed:18997320, ECO:0000269|PubMed:20691033, ECO:0000269|PubMed:25667979
ChainResidueDetails
AVAL42

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P12815
ChainResidueDetails
AASP169
AASP171
AASP173
ATRP175

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PDB entries from 2024-10-30

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