2ZND
Crystal structure of Ca2+-free form of des3-20ALG-2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0001525 | biological_process | angiogenesis |
| A | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| A | 0006915 | biological_process | apoptotic process |
| A | 0010595 | biological_process | positive regulation of endothelial cell migration |
| A | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| A | 0014029 | biological_process | neural crest formation |
| A | 0014032 | biological_process | neural crest cell development |
| A | 0030127 | cellular_component | COPII vesicle coat |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0030948 | biological_process | negative regulation of vascular endothelial growth factor receptor signaling pathway |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| A | 0032007 | biological_process | negative regulation of TOR signaling |
| A | 0034605 | biological_process | cellular response to heat |
| A | 0036324 | biological_process | vascular endothelial growth factor receptor-2 signaling pathway |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0043495 | molecular_function | protein-membrane adaptor activity |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0048208 | biological_process | COPII vesicle coating |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051592 | biological_process | response to calcium ion |
| A | 0051898 | biological_process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070971 | cellular_component | endoplasmic reticulum exit site |
| A | 0097190 | biological_process | apoptotic signaling pathway |
| A | 1902527 | biological_process | positive regulation of protein monoubiquitination |
| A | 1990756 | molecular_function | ubiquitin-like ligase-substrate adaptor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MRD A 1 |
| Chain | Residue |
| A | ARG66 |
| A | SER70 |
| A | ASP73 |
| A | ASN76 |
| A | LYS77 |
| A | ALA78 |
| A | HOH307 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MRD A 2 |
| Chain | Residue |
| A | GLY55 |
| A | GLN96 |
| A | ARG100 |
| A | PHE148 |
| A | SER53 |
| A | ASN54 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MRD A 3 |
| Chain | Residue |
| A | THR162 |
| A | ASP169 |
| A | GLY174 |
| A | HOH205 |
| A | HOH234 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD A 4 |
| Chain | Residue |
| A | MRD5 |
| A | ASP94 |
| A | TRP95 |
| A | VAL98 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MRD A 5 |
| Chain | Residue |
| A | MRD4 |
| A | ARG104 |
| A | PHE122 |
| A | TYR124 |
| A | GLN159 |
| A | HOH207 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PO4 A 192 |
| Chain | Residue |
| A | ARG140 |
| A | GLN141 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PO4 A 193 |
| Chain | Residue |
| A | PHE188 |
| A | HOH280 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 194 |
| Chain | Residue |
| A | ASP36 |
| A | ASP38 |
| A | SER40 |
| A | VAL42 |
| A | GLU47 |
| A | HOH268 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 195 |
| Chain | Residue |
| A | ASP103 |
| A | ASP105 |
| A | SER107 |
| A | MET109 |
| A | HOH221 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 196 |
| Chain | Residue |
| A | ASP169 |
| A | ASP171 |
| A | ASP173 |
| A | TRP175 |
| A | HOH223 |
| A | HOH252 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDRSGVISdtEL |
| Chain | Residue | Details |
| A | ASP36-LEU48 | |
| A | ASP103-LEU115 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 29 |
| Details | Domain: {"description":"EF-hand 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18940611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18997320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20691033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25667979","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18940611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18997320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20691033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25667979","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P12815","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
