2ZMI

Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TT2 A 1

Chain	Residue
A	TYR143
A	CYS284
A	ALA299
A	HIS301
A	HIS393
A	LEU410
A	LEU223
A	ALA227
A	SER233
A	MET268
A	ARG270
A	SER271
A	SER274
A	TRP282

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 424

Chain	Residue
A	PRO412
A	LEU415
A	ASN420
A	HOH496

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 425

Chain	Residue
A	SER356
A	HOH439

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"UniProtKB","id":"P11473","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RK3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

---