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2ZLE

Cryo-EM structure of DegP12/OMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006457biological_processprotein folding
A0006508biological_processproteolysis
A0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
A0006979biological_processresponse to oxidative stress
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009266biological_processresponse to temperature stimulus
A0009408biological_processresponse to heat
A0030288cellular_componentouter membrane-bounded periplasmic space
A0042597cellular_componentperiplasmic space
A0042802molecular_functionidentical protein binding
A0061077biological_processchaperone-mediated protein folding
B0004175molecular_functionendopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006457biological_processprotein folding
B0006508biological_processproteolysis
B0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
B0006979biological_processresponse to oxidative stress
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0009266biological_processresponse to temperature stimulus
B0009408biological_processresponse to heat
B0030288cellular_componentouter membrane-bounded periplasmic space
B0042597cellular_componentperiplasmic space
B0042802molecular_functionidentical protein binding
B0061077biological_processchaperone-mediated protein folding
C0004175molecular_functionendopeptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006457biological_processprotein folding
C0006508biological_processproteolysis
C0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
C0006979biological_processresponse to oxidative stress
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0009266biological_processresponse to temperature stimulus
C0009408biological_processresponse to heat
C0030288cellular_componentouter membrane-bounded periplasmic space
C0042597cellular_componentperiplasmic space
C0042802molecular_functionidentical protein binding
C0061077biological_processchaperone-mediated protein folding
D0001618molecular_functionvirus receptor activity
D0005515molecular_functionprotein binding
D0006811biological_processmonoatomic ion transport
D0006974biological_processDNA damage response
D0009279cellular_componentcell outer membrane
D0015288molecular_functionporin activity
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0046718biological_processsymbiont entry into host cell
D0046813biological_processreceptor-mediated virion attachment to host cell
D0046872molecular_functionmetal ion binding
D0046930cellular_componentpore complex
D0120010biological_processintermembrane phospholipid transfer
E0004175molecular_functionendopeptidase activity
E0004252molecular_functionserine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006457biological_processprotein folding
E0006508biological_processproteolysis
E0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
E0006979biological_processresponse to oxidative stress
E0008233molecular_functionpeptidase activity
E0008236molecular_functionserine-type peptidase activity
E0009266biological_processresponse to temperature stimulus
E0009408biological_processresponse to heat
E0030288cellular_componentouter membrane-bounded periplasmic space
E0042597cellular_componentperiplasmic space
E0042802molecular_functionidentical protein binding
E0061077biological_processchaperone-mediated protein folding
F0004175molecular_functionendopeptidase activity
F0004252molecular_functionserine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006457biological_processprotein folding
F0006508biological_processproteolysis
F0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
F0006979biological_processresponse to oxidative stress
F0008233molecular_functionpeptidase activity
F0008236molecular_functionserine-type peptidase activity
F0009266biological_processresponse to temperature stimulus
F0009408biological_processresponse to heat
F0030288cellular_componentouter membrane-bounded periplasmic space
F0042597cellular_componentperiplasmic space
F0042802molecular_functionidentical protein binding
F0061077biological_processchaperone-mediated protein folding
G0004175molecular_functionendopeptidase activity
G0004252molecular_functionserine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006457biological_processprotein folding
G0006508biological_processproteolysis
G0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
G0006979biological_processresponse to oxidative stress
G0008233molecular_functionpeptidase activity
G0008236molecular_functionserine-type peptidase activity
G0009266biological_processresponse to temperature stimulus
G0009408biological_processresponse to heat
G0030288cellular_componentouter membrane-bounded periplasmic space
G0042597cellular_componentperiplasmic space
G0042802molecular_functionidentical protein binding
G0061077biological_processchaperone-mediated protein folding
H0004175molecular_functionendopeptidase activity
H0004252molecular_functionserine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006457biological_processprotein folding
H0006508biological_processproteolysis
H0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
H0006979biological_processresponse to oxidative stress
H0008233molecular_functionpeptidase activity
H0008236molecular_functionserine-type peptidase activity
H0009266biological_processresponse to temperature stimulus
H0009408biological_processresponse to heat
H0030288cellular_componentouter membrane-bounded periplasmic space
H0042597cellular_componentperiplasmic space
H0042802molecular_functionidentical protein binding
H0061077biological_processchaperone-mediated protein folding
I0004175molecular_functionendopeptidase activity
I0004252molecular_functionserine-type endopeptidase activity
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0006457biological_processprotein folding
I0006508biological_processproteolysis
I0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
I0006979biological_processresponse to oxidative stress
I0008233molecular_functionpeptidase activity
I0008236molecular_functionserine-type peptidase activity
I0009266biological_processresponse to temperature stimulus
I0009408biological_processresponse to heat
I0030288cellular_componentouter membrane-bounded periplasmic space
I0042597cellular_componentperiplasmic space
I0042802molecular_functionidentical protein binding
I0061077biological_processchaperone-mediated protein folding
J0004175molecular_functionendopeptidase activity
J0004252molecular_functionserine-type endopeptidase activity
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0006457biological_processprotein folding
J0006508biological_processproteolysis
J0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
J0006979biological_processresponse to oxidative stress
J0008233molecular_functionpeptidase activity
J0008236molecular_functionserine-type peptidase activity
J0009266biological_processresponse to temperature stimulus
J0009408biological_processresponse to heat
J0030288cellular_componentouter membrane-bounded periplasmic space
J0042597cellular_componentperiplasmic space
J0042802molecular_functionidentical protein binding
J0061077biological_processchaperone-mediated protein folding
K0004175molecular_functionendopeptidase activity
K0004252molecular_functionserine-type endopeptidase activity
K0005515molecular_functionprotein binding
K0005886cellular_componentplasma membrane
K0006457biological_processprotein folding
K0006508biological_processproteolysis
K0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
K0006979biological_processresponse to oxidative stress
K0008233molecular_functionpeptidase activity
K0008236molecular_functionserine-type peptidase activity
K0009266biological_processresponse to temperature stimulus
K0009408biological_processresponse to heat
K0030288cellular_componentouter membrane-bounded periplasmic space
K0042597cellular_componentperiplasmic space
K0042802molecular_functionidentical protein binding
K0061077biological_processchaperone-mediated protein folding
L0004175molecular_functionendopeptidase activity
L0004252molecular_functionserine-type endopeptidase activity
L0005515molecular_functionprotein binding
L0005886cellular_componentplasma membrane
L0006457biological_processprotein folding
L0006508biological_processproteolysis
L0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
L0006979biological_processresponse to oxidative stress
L0008233molecular_functionpeptidase activity
L0008236molecular_functionserine-type peptidase activity
L0009266biological_processresponse to temperature stimulus
L0009408biological_processresponse to heat
L0030288cellular_componentouter membrane-bounded periplasmic space
L0042597cellular_componentperiplasmic space
L0042802molecular_functionidentical protein binding
L0061077biological_processchaperone-mediated protein folding
M0004175molecular_functionendopeptidase activity
M0004252molecular_functionserine-type endopeptidase activity
M0005515molecular_functionprotein binding
M0005886cellular_componentplasma membrane
M0006457biological_processprotein folding
M0006508biological_processproteolysis
M0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
M0006979biological_processresponse to oxidative stress
M0008233molecular_functionpeptidase activity
M0008236molecular_functionserine-type peptidase activity
M0009266biological_processresponse to temperature stimulus
M0009408biological_processresponse to heat
M0030288cellular_componentouter membrane-bounded periplasmic space
M0042597cellular_componentperiplasmic space
M0042802molecular_functionidentical protein binding
M0061077biological_processchaperone-mediated protein folding
Functional Information from PROSITE/UniProt
site_idPS00576
Number of Residues17
DetailsGRAM_NEG_PORIN General diffusion Gram-negative porins signature. VdvGatYyFnKnmSTYV
ChainResidueDetails
DVAL1486-VAL1502

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues46
DetailsTOPO_DOM: Periplasmic => ECO:0000269|PubMed:16949612
ChainResidueDetails
DALA1189-ASP1200
EHIS1602
EASP1632
ESER1699
FHIS1998
FASP2028
FSER2095
GHIS2394
GASP2424
GSER2491
HHIS2790
DGLU1231-GLY1240
HASP2820
HSER2887
IHIS3186
IASP3216
ISER3283
JHIS3582
JASP3612
JSER3679
KHIS3978
KASP4008
DLYS1269-VAL1273
KSER4075
LHIS4374
LASP4404
LSER4471
MHIS4770
MASP4800
MSER4867
DTHR1322-GLY1330
DASP1375-GLY1378
DASP1416-ASN1419
DGLN1454-GLY1458
DPHE1494-ASN1497
DPHE1534

site_idSWS_FT_FI2
Number of Residues133
DetailsTRANSMEM: Beta stranded
ChainResidueDetails
DLEU1201-HIS1209
DTYR1409-TYR1415
DILE1420-THR1427
DSER1437-TYR1453
DLEU1459-LEU1466
DVAL1486-TYR1493
DMET1498-LYS1505
DVAL1526-GLN1533
CTHR973
CLEU1012
EGLU1556
DGLN1221-GLY1230
EHIS1602
EASP1632
EGLY1697
ETHR1715
ELEU1754
FGLU1952
FHIS1998
FASP2028
FGLY2093
FTHR2111
DTYR1241-ASN1251
FLEU2150
GGLU2348
GHIS2394
GASP2424
GGLY2489
GTHR2507
GLEU2546
HGLU2744
HHIS2790
HASP2820
DSER1259-LEU1268
HGLY2885
HTHR2903
HLEU2942
IGLU3140
IHIS3186
IASP3216
IGLY3281
ITHR3299
ILEU3338
JGLU3536
DGLY1274-TYR1282
JHIS3582
JASP3612
JGLY3677
JTHR3695
JLEU3734
KGLU3932
KHIS3978
KASP4008
KGLY4073
KTHR4091
DMET1309-ASN1321
KLEU4130
LGLU4328
LHIS4374
LASP4404
LGLY4469
LTHR4487
LLEU4526
MGLU4724
MHIS4770
MASP4800
DLEU1331-GLN1338
MGLY4865
MTHR4883
MLEU4922
DVAL1368-TYR1374
DPHE1379-SER1386

site_idSWS_FT_FI3
Number of Residues135
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:16949612
ChainResidueDetails
DTYR1210-ASP1220
DSER1252-ASN1258
DGLY1283-PHE1308
DGLY1339-GLY1367
DSER1387-THR1408
DGLN1428-GLY1436
DGLN1467-TYR1485
DILE1506-ILE1525

site_idSWS_FT_FI4
Number of Residues3
DetailsBINDING: BINDING => ECO:0007744|PDB:2J1N
ChainResidueDetails
DASN1507
DLEU1509
DTHR1522

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
AASP98
AHIS68
ASER165
AGLY163

site_idCSA10
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
KHIS3978
KASP4008
KSER4075
KGLY4073

site_idCSA11
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
LHIS4374
LGLY4469
LASP4404
LSER4471

site_idCSA12
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
MASP4800
MSER4867
MGLY4865
MHIS4770

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
BASP494
BSER561
BGLY559
BHIS464

site_idCSA3
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
CSER957
CGLY955
CASP890
CHIS860

site_idCSA4
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
EGLY1697
EASP1632
EHIS1602
ESER1699

site_idCSA5
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
FASP2028
FHIS1998
FGLY2093
FSER2095

site_idCSA6
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
GHIS2394
GASP2424
GGLY2489
GSER2491

site_idCSA7
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
HGLY2885
HSER2887
HHIS2790
HASP2820

site_idCSA8
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
IASP3216
IGLY3281
ISER3283
IHIS3186

site_idCSA9
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ds2
ChainResidueDetails
JGLY3677
JASP3612
JHIS3582
JSER3679

222415

PDB entries from 2024-07-10

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