2ZLC

2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation and crystal structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE VDX A 500

Chain	Residue
A	TYR143
A	HIS301
A	LEU305
A	HIS393
A	TYR397
A	LEU229
A	SER233
A	ILE267
A	ARG270
A	SER271
A	SER274
A	TRP282
A	CYS284

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:15065852, ECO:0007744|PDB:1RK3

Chain	Residue	Details
A	TYR143
A	MET280
A	LYS317
A	LEU321
A	VAL348

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