2ZL9

2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation and crystal structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE VDA A 500

Chain	Residue
A	THR142
A	TRP282
A	CYS284
A	HIS301
A	HIS393
A	TYR143
A	LEU223
A	LEU226
A	ALA227
A	SER233
A	ARG270
A	SER271
A	SER274

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RK3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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