Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2ZL4

Crystal structure of H.pylori ClpP S99A in complex with the peptide AAAA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0051117	molecular_function	ATPase binding

Functional Information from PROSITE/UniProt

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfslPhsrIMIHQP

Chain	Residue	Details
A	ARG113-PRO126

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	ALA99
J	ALA99
K	ALA99
L	ALA99
M	ALA99
N	ALA99
B	ALA99
C	ALA99
D	ALA99
E	ALA99
F	ALA99
G	ALA99
H	ALA99
I	ALA99

site_id	SWS_FT_FI2
Number of Residues	14
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	HIS124
J	HIS124
K	HIS124
L	HIS124
M	HIS124
N	HIS124
B	HIS124
C	HIS124
D	HIS124
E	HIS124
F	HIS124
G	HIS124
H	HIS124
I	HIS124

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
A	MET100
A	HIS124
A	ALA99
A	ASP173
A	GLY70

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
B	MET100
B	HIS124
B	ALA99
B	ASP173
B	GLY70

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
C	MET100
C	HIS124
C	ALA99
C	ASP173
C	GLY70

site_id	CSA4
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
D	MET100
D	HIS124
D	ALA99
D	ASP173
D	GLY70

site_id	CSA5
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
E	MET100
E	HIS124
E	ALA99
E	ASP173
E	GLY70

site_id	CSA6
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
F	MET100
F	HIS124
F	ALA99
F	ASP173
F	GLY70

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
G	MET100
G	HIS124
G	ALA99
G	ASP173
G	GLY70

site_id	CSA8
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
H	MET100
H	HIS124
H	ALA99
H	ASP173
H	GLY70

site_id	CSA9
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
I	MET100
I	HIS124
I	ALA99
I	ASP173
I	GLY70

site_id	CSA10
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
J	MET100
J	HIS124
J	ALA99
J	ASP173
J	GLY70

site_id	CSA11
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
K	MET100
K	HIS124
K	ALA99
K	ASP173
K	GLY70

site_id	CSA12
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
L	MET100
L	HIS124
L	ALA99
L	ASP173
L	GLY70

site_id	CSA13
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
M	MET100
M	HIS124
M	ALA99
M	ASP173
M	GLY70

site_id	CSA14
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
N	MET100
N	HIS124
N	ALA99
N	ASP173
N	GLY70

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)