2ZHJ
Crystal Structure Analysis of the Sodium-Bound Annexin A4 at 1.34 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006887 | biological_process | exocytosis |
| A | 0007219 | biological_process | Notch signaling pathway |
| A | 0009986 | cellular_component | cell surface |
| A | 0010804 | biological_process | negative regulation of tumor necrosis factor-mediated signaling pathway |
| A | 0012506 | cellular_component | vesicle membrane |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0032717 | biological_process | negative regulation of interleukin-8 production |
| A | 0042589 | cellular_component | zymogen granule membrane |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043124 | biological_process | negative regulation of canonical NF-kappaB signal transduction |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051059 | molecular_function | NF-kappaB binding |
| A | 0140416 | molecular_function | transcription regulator inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 320 |
| Chain | Residue |
| A | MET99 |
| A | GLY101 |
| A | GLY103 |
| A | ASP143 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 321 |
| Chain | Residue |
| A | HOH440 |
| A | GLY182 |
| A | ARG185 |
| A | GLY187 |
| A | GLU227 |
| A | HOH416 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GTdedaiigvLacRntaQrqEirtaYkstigrdLledLkselsSnfeqvIlgM |
| Chain | Residue | Details |
| A | GLY31-MET83 | |
| A | GLY103-LEU155 | |
| A | GLY187-ILE239 | |
| A | GLY262-LEU314 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 72 |
| Details | Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 71 |
| Details | Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P08132","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P09525","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P09525","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
