2ZFZ

Crystal structure of the C-terminal domain hexamer of ArgR from Mycobacterium tuberculosis in complex with arginine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0034618	molecular_function	arginine binding
A	0051259	biological_process	protein complex oligomerization
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0034618	molecular_function	arginine binding
B	0051259	biological_process	protein complex oligomerization
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0034618	molecular_function	arginine binding
C	0051259	biological_process	protein complex oligomerization
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0034618	molecular_function	arginine binding
D	0051259	biological_process	protein complex oligomerization
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0034618	molecular_function	arginine binding
E	0051259	biological_process	protein complex oligomerization
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0034618	molecular_function	arginine binding
F	0051259	biological_process	protein complex oligomerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ARG A 300

Chain	Residue
A	HIS125
C	ASP146
C	ASP147
C	THR148
F	PRO121
F	GLY122
F	ASP146
A	ALA128
A	ASP132
A	THR142
A	ILE143
A	ALA144
A	HOH508
A	HOH512
C	GLY145

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ARG B 300

Chain	Residue
A	GLY145
A	ASP146
A	ASP147
A	THR148
B	HIS125
B	ALA128
B	ASP132
B	THR142
B	ILE143
B	ALA144
B	HOH534
B	HOH547
E	GLY122
E	ASP146

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ARG C 300

Chain	Residue
B	ARG118
B	GLY145
B	ASP146
B	ASP147
B	THR148
C	HIS125
C	ALA128
C	ASP132
C	THR142
C	ILE143
C	ALA144
C	HOH507
C	HOH508
D	PRO121
D	GLY122
D	ASP146

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ARG D 300

Chain	Residue
C	GLY122
C	ASP146
D	HIS125
D	ALA128
D	ASP132
D	THR142
D	ILE143
D	ALA144
D	HOH568
D	HOH579
F	GLY145
F	ASP146
F	ASP147
F	THR148

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ARG E 300

Chain	Residue
B	PRO121
B	ASP146
D	GLY145
D	ASP146
D	ASP147
D	THR148
E	HIS125
E	ALA128
E	ASP132
E	THR142
E	ILE143
E	ALA144
E	HOH583
E	HOH586

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ARG F 300

Chain	Residue
A	PRO121
A	ASP146
E	GLY145
E	ASP146
E	ASP147
E	THR148
F	HIS125
F	ALA128
F	ASP132
F	THR142
F	ILE143
F	ALA144
F	HOH507
F	HOH512

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GAI A 400

Chain	Residue
A	GLY164
A	GLU167
A	ASN168
E	GLY102
E	GLU103
E	LEU105

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GAI E 400

Chain	Residue
A	LEU105
A	VAL106
A	GLU167
A	ARG170
A	HOH551

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