2ZCH

Crystal structure of human prostate specific antigen complexed with an activating antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0002803	biological_process	positive regulation of antibacterial peptide production
P	0004175	molecular_function	endopeptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0006508	biological_process	proteolysis
P	0008236	molecular_function	serine-type peptidase activity
P	0016525	biological_process	negative regulation of angiogenesis
P	0016787	molecular_function	hydrolase activity
P	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
P	0030141	cellular_component	secretory granule
P	0032991	cellular_component	protein-containing complex
P	0051604	biological_process	protein maturation
P	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
P	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. STcsGDSGGPLV

Chain	Residue	Details
P	SER189-VAL200

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:18187150

Chain	Residue	Details
P	HIS57
P	ASP102
P	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
P	ASN61

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