2ZBA

Crystal Structure of F. sporotrichioides TRI101 complexed with Coenzyme A and T-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE COA A 462

Chain	Residue
A	ASP169
A	ASP302
A	GLN318
A	ARG343
A	SER386
A	SER387
A	TRP388
A	LYS390
A	ZBA463
A	HOH1036
A	HOH1043
A	MSE170
A	HOH1047
A	HOH1068
A	HOH1104
A	HOH1157
A	LYS253
A	PHE266
A	SER268
A	THR269
A	ASP270
A	ALA300
A	VAL301

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ZBA A 463

Chain	Residue
A	PRO24
A	LEU25
A	ILE28
A	HIS165
A	GLN318
A	MSE320
A	SER372
A	THR374
A	MSE384
A	SER386
A	PHE416
A	LEU419
A	TYR421
A	COA462

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 460

Chain	Residue
A	ASP218
A	ASP376
A	HOH1046
A	HOH1066
A	HOH1139

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 461

Chain	Residue
A	ASP218
A	ILE221
A	ASP376
A	HOH1001

---

site_id	AC5
Number of Residues	26
Details	BINDING SITE FOR RESIDUE COA B 460

Chain	Residue
B	MSE170
B	LYS253
B	PHE266
B	SER268
B	THR269
B	ASP270
B	ALA300
B	VAL301
B	ASP302
B	GLN318
B	ARG343
B	SER386
B	SER387
B	TRP388
B	LYS390
B	ZBA461
B	HOH1014
B	HOH1019
B	HOH1032
B	HOH1047
B	HOH1056
B	HOH1059
B	HOH1126
B	HOH1175
B	HOH1223
C	COA460

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ZBA B 461

Chain	Residue
B	LEU25
B	ILE28
B	HIS165
B	GLN318
B	MSE320
B	LEU373
B	THR374
B	SER386
B	PHE416
B	LEU419
B	TYR421
B	COA460

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS B 462

Chain	Residue
B	PRO41
B	ARG99
B	HOH1110

---

site_id	AC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE COA C 460

Chain	Residue
C	SER386
C	SER387
C	TRP388
C	LYS390
C	ZBA461
C	GOL462
C	HOH1027
C	HOH1040
C	HOH1045
C	HOH1047
C	HOH1088
C	HOH1173
C	HOH1209
C	HOH1300
B	COA460
C	ASP169
C	MSE170
C	LYS253
C	PHE266
C	SER268
C	THR269
C	ALA300
C	VAL301
C	ASP302
C	GLN318
C	ARG343

---

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ZBA C 461

Chain	Residue
C	HIS165
C	GLN318
C	MSE320
C	SER372
C	THR374
C	SER386
C	PHE416
C	LEU419
C	TYR421
C	COA460
C	HOH1175

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 462

Chain	Residue
C	VAL301
C	ASP302
C	COA460
C	HOH1215

---

site_id	BC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE COA D 460

Chain	Residue
D	ASP169
D	MSE170
D	LYS253
D	PHE266
D	SER268
D	THR269
D	ALA300
D	VAL301
D	ASP302
D	GLN318
D	ARG343
D	SER386
D	SER387
D	TRP388
D	LYS390
D	ZBA461
D	HOH1032
D	HOH1056
D	HOH1061
D	HOH1062
D	HOH1091
D	HOH1100
D	HOH1108
D	HOH1160

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ZBA D 461

Chain	Residue
D	GLN22
D	LEU25
D	ILE28
D	HIS165
D	GLN318
D	SER386
D	LEU419
D	TYR421
D	COA460

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000269|PubMed:17923480, ECO:0007744|PDB:2ZBA

Chain	Residue	Details
A	ASP218
A	GLU449
B	ASP218
B	ILE221
B	LYS253
B	ASP302
B	GLN318
B	ARG343
B	ASP376
B	SER386
B	LYS390
A	ILE221
B	GLU449
C	ASP218
C	ILE221
C	LYS253
C	ASP302
C	GLN318
C	ARG343
C	ASP376
C	SER386
C	LYS390
A	LYS253
C	GLU449
D	ASP218
D	ILE221
D	LYS253
D	ASP302
D	GLN318
D	ARG343
D	ASP376
D	SER386
D	LYS390
A	ASP302
D	GLU449
A	GLN318
A	ARG343
A	ASP376
A	SER386
A	LYS390

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0007744|PDB:2ZBA

Chain	Residue	Details
A	PHE266
B	PHE266
C	PHE266
D	PHE266

---