2ZB0
Crystal structure of P38 in complex with biphenyl amide inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000922 | cellular_component | spindle pole |
| A | 0001502 | biological_process | cartilage condensation |
| A | 0001649 | biological_process | osteoblast differentiation |
| A | 0002021 | biological_process | response to dietary excess |
| A | 0002862 | biological_process | negative regulation of inflammatory response to antigenic stimulus |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004707 | molecular_function | MAP kinase activity |
| A | 0004708 | molecular_function | MAP kinase kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0007165 | biological_process | signal transduction |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0010831 | biological_process | positive regulation of myotube differentiation |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019903 | molecular_function | protein phosphatase binding |
| A | 0030168 | biological_process | platelet activation |
| A | 0030316 | biological_process | osteoclast differentiation |
| A | 0031098 | biological_process | stress-activated protein kinase signaling cascade |
| A | 0031281 | biological_process | positive regulation of cyclase activity |
| A | 0032735 | biological_process | positive regulation of interleukin-12 production |
| A | 0032868 | biological_process | response to insulin |
| A | 0033209 | biological_process | tumor necrosis factor-mediated signaling pathway |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0035331 | biological_process | negative regulation of hippo signaling |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0035924 | biological_process | cellular response to vascular endothelial growth factor stimulus |
| A | 0038066 | biological_process | p38MAPK cascade |
| A | 0042770 | biological_process | signal transduction in response to DNA damage |
| A | 0043536 | biological_process | positive regulation of blood vessel endothelial cell migration |
| A | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
| A | 0045663 | biological_process | positive regulation of myoblast differentiation |
| A | 0048010 | biological_process | vascular endothelial growth factor receptor signaling pathway |
| A | 0048273 | molecular_function | mitogen-activated protein kinase p38 binding |
| A | 0051149 | biological_process | positive regulation of muscle cell differentiation |
| A | 0051403 | biological_process | stress-activated MAPK cascade |
| A | 0051525 | molecular_function | NFAT protein binding |
| A | 0060348 | biological_process | bone development |
| A | 0070935 | biological_process | 3'-UTR-mediated mRNA stabilization |
| A | 0071222 | biological_process | cellular response to lipopolysaccharide |
| A | 0071223 | biological_process | cellular response to lipoteichoic acid |
| A | 0071479 | biological_process | cellular response to ionizing radiation |
| A | 0071493 | biological_process | cellular response to UV-B |
| A | 0090090 | biological_process | negative regulation of canonical Wnt signaling pathway |
| A | 0090398 | biological_process | cellular senescence |
| A | 0090400 | biological_process | stress-induced premature senescence |
| A | 0098586 | biological_process | cellular response to virus |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099179 | biological_process | regulation of synaptic membrane adhesion |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 1900015 | biological_process | regulation of cytokine production involved in inflammatory response |
| A | 1901741 | biological_process | positive regulation of myoblast fusion |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| A | 2000379 | biological_process | positive regulation of reactive oxygen species metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GK3 A 361 |
| Chain | Residue |
| A | VAL30 |
| A | LEU171 |
| A | ALA51 |
| A | GLU71 |
| A | LEU75 |
| A | THR106 |
| A | LEU108 |
| A | MET109 |
| A | ASP168 |
| A | PHE169 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 362 |
| Chain | Residue |
| A | TYR69 |
| A | TYR182 |
| A | THR221 |
| A | SER326 |
| A | PHE327 |
| A | ARG330 |
| A | HOH390 |
| A | HOH411 |
| A | HOH467 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK |
| Chain | Residue | Details |
| A | VAL30-LYS54 |
| site_id | PS01351 |
| Number of Residues | 104 |
| Details | MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC |
| Chain | Residue | Details |
| A | PHE59-CYS162 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 284 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Motif: {"description":"TXY"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21444723","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"source":"PubMed","id":"7535770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"source":"PubMed","id":"7535770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"source":"PubMed","id":"15735648","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | SER154 | |
| A | ASP150 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS152 | |
| A | ASP150 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS152 | |
| A | THR185 | |
| A | ASP150 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASN155 | |
| A | LYS152 | |
| A | ASP150 |
