2ZA3
Crystal Structure of orotidine 5'-monophosphate decarboxylase complexed with uridine 5'-monophosphate from P.falciparum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE U5P A 500 |
| Chain | Residue |
| A | ASP23 |
| A | GLY293 |
| A | ARG294 |
| A | HOH511 |
| A | HOH512 |
| A | HOH514 |
| A | HOH515 |
| B | ASP141 |
| B | MET168 |
| A | ASN104 |
| A | ASP136 |
| A | LYS138 |
| A | THR194 |
| A | THR195 |
| A | PRO264 |
| A | GLN269 |
| A | ASN291 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE U5P B 600 |
| Chain | Residue |
| A | ASP141 |
| A | ILE142 |
| A | THR145 |
| B | ASP23 |
| B | LYS102 |
| B | ASN104 |
| B | ASP136 |
| B | THR194 |
| B | THR195 |
| B | PRO264 |
| B | GLN269 |
| B | ASN291 |
| B | GLY293 |
| B | ARG294 |
| B | HOH601 |
| B | HOH609 |
| B | HOH624 |
| B | HOH625 |
Functional Information from PROSITE/UniProt
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. TIlDmKinDIGnTV |
| Chain | Residue | Details |
| A | THR133-VAL146 |
