2Z9V
Crystal structure of pyridoxamine-pyruvate aminotransferase complexed with pyridoxamine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004760 | molecular_function | L-serine-pyruvate transaminase activity |
| A | 0008453 | molecular_function | alanine-glyoxylate transaminase activity |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019265 | biological_process | glycine biosynthetic process, by transamination of glyoxylate |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0047300 | molecular_function | pyridoxamine-pyruvate transaminase activity |
| B | 0004760 | molecular_function | L-serine-pyruvate transaminase activity |
| B | 0008453 | molecular_function | alanine-glyoxylate transaminase activity |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019265 | biological_process | glycine biosynthetic process, by transamination of glyoxylate |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0047300 | molecular_function | pyridoxamine-pyruvate transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1601 |
| Chain | Residue |
| A | ALA16 |
| A | TYR95 |
| A | THR146 |
| A | LYS197 |
| A | ARG336 |
| A | ARG345 |
| A | PXM1501 |
| A | HOH1616 |
| A | HOH1807 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1603 |
| Chain | Residue |
| A | LYS219 |
| A | ARG226 |
| A | VAL233 |
| A | HOH1719 |
| A | HOH1737 |
| A | HOH1767 |
| A | HOH1938 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2601 |
| Chain | Residue |
| B | ALA16 |
| B | TYR95 |
| B | THR146 |
| B | PRO147 |
| B | LYS197 |
| B | ARG336 |
| B | ARG345 |
| B | PXM2501 |
| B | HOH2635 |
| B | HOH2756 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2602 |
| Chain | Residue |
| B | PRO5 |
| B | GLU6 |
| B | HIS7 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2604 |
| Chain | Residue |
| B | ARG310 |
| B | PRO312 |
| B | ASP313 |
| B | ARG374 |
| B | HOH2749 |
| B | HOH2794 |
| B | HOH2811 |
| B | HOH2959 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PXM A 1501 |
| Chain | Residue |
| A | GLU68 |
| A | PRO69 |
| A | VAL70 |
| A | LEU73 |
| A | TYR95 |
| A | HIS144 |
| A | THR146 |
| A | ASP171 |
| A | SO41601 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PXM B 2501 |
| Chain | Residue |
| B | GLU68 |
| B | VAL70 |
| B | LEU73 |
| B | TYR95 |
| B | HIS144 |
| B | THR146 |
| B | ASP171 |
| B | VAL173 |
| B | SO42601 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 953 |
| Chain | Residue |
| A | SER298 |
| A | ASP299 |
| A | SER300 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 954 |
| Chain | Residue |
| B | SER298 |
| B | ASP299 |
| B | SER300 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 955 |
| Chain | Residue |
| A | GLY98 |
| A | TYR101 |
| A | TRP102 |
| A | HOH1636 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 956 |
| Chain | Residue |
| B | GLY98 |
| B | TYR101 |
| B | TRP102 |
| B | HOH2733 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17989071","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"17989071","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| A | TYR95 | |
| A | ASP171 | |
| A | LYS217 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| B | TYR95 | |
| B | ASP171 | |
| B | LYS217 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| A | TYR95 | |
| A | LYS197 | |
| A | ASP171 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b8g |
| Chain | Residue | Details |
| B | TYR95 | |
| B | LYS197 | |
| B | ASP171 |
