Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2Z9S

Crystal Structure Analysis of rat HBP23/Peroxiredoxin I, Cys52Ser mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0000791	cellular_component	euchromatin
A	0004601	molecular_function	peroxidase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005759	cellular_component	mitochondrial matrix
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008283	biological_process	cell population proliferation
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0020037	molecular_function	heme binding
A	0030101	biological_process	natural killer cell activation
A	0032872	biological_process	regulation of stress-activated MAPK cascade
A	0034101	biological_process	erythrocyte homeostasis
A	0042267	biological_process	natural killer cell mediated cytotoxicity
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045321	biological_process	leukocyte activation
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	0000302	biological_process	response to reactive oxygen species
B	0000791	cellular_component	euchromatin
B	0004601	molecular_function	peroxidase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005759	cellular_component	mitochondrial matrix
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008283	biological_process	cell population proliferation
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0020037	molecular_function	heme binding
B	0030101	biological_process	natural killer cell activation
B	0032872	biological_process	regulation of stress-activated MAPK cascade
B	0034101	biological_process	erythrocyte homeostasis
B	0042267	biological_process	natural killer cell mediated cytotoxicity
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045321	biological_process	leukocyte activation
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	0000302	biological_process	response to reactive oxygen species
C	0000791	cellular_component	euchromatin
C	0004601	molecular_function	peroxidase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005759	cellular_component	mitochondrial matrix
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008283	biological_process	cell population proliferation
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0020037	molecular_function	heme binding
C	0030101	biological_process	natural killer cell activation
C	0032872	biological_process	regulation of stress-activated MAPK cascade
C	0034101	biological_process	erythrocyte homeostasis
C	0042267	biological_process	natural killer cell mediated cytotoxicity
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0045321	biological_process	leukocyte activation
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	0000302	biological_process	response to reactive oxygen species
D	0000791	cellular_component	euchromatin
D	0004601	molecular_function	peroxidase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005759	cellular_component	mitochondrial matrix
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008283	biological_process	cell population proliferation
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0020037	molecular_function	heme binding
D	0030101	biological_process	natural killer cell activation
D	0032872	biological_process	regulation of stress-activated MAPK cascade
D	0034101	biological_process	erythrocyte homeostasis
D	0042267	biological_process	natural killer cell mediated cytotoxicity
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0045321	biological_process	leukocyte activation
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	0000302	biological_process	response to reactive oxygen species
E	0000791	cellular_component	euchromatin
E	0004601	molecular_function	peroxidase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005759	cellular_component	mitochondrial matrix
E	0005782	cellular_component	peroxisomal matrix
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008283	biological_process	cell population proliferation
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0019430	biological_process	removal of superoxide radicals
E	0020037	molecular_function	heme binding
E	0030101	biological_process	natural killer cell activation
E	0032872	biological_process	regulation of stress-activated MAPK cascade
E	0034101	biological_process	erythrocyte homeostasis
E	0042267	biological_process	natural killer cell mediated cytotoxicity
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042802	molecular_function	identical protein binding
E	0045321	biological_process	leukocyte activation
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	0000302	biological_process	response to reactive oxygen species
F	0000791	cellular_component	euchromatin
F	0004601	molecular_function	peroxidase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005759	cellular_component	mitochondrial matrix
F	0005782	cellular_component	peroxisomal matrix
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0008283	biological_process	cell population proliferation
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0019430	biological_process	removal of superoxide radicals
F	0020037	molecular_function	heme binding
F	0030101	biological_process	natural killer cell activation
F	0032872	biological_process	regulation of stress-activated MAPK cascade
F	0034101	biological_process	erythrocyte homeostasis
F	0042267	biological_process	natural killer cell mediated cytotoxicity
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042802	molecular_function	identical protein binding
F	0045321	biological_process	leukocyte activation
F	0045454	biological_process	cell redox homeostasis
F	0051920	molecular_function	peroxiredoxin activity
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
G	0000302	biological_process	response to reactive oxygen species
G	0000791	cellular_component	euchromatin
G	0004601	molecular_function	peroxidase activity
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005759	cellular_component	mitochondrial matrix
G	0005782	cellular_component	peroxisomal matrix
G	0005829	cellular_component	cytosol
G	0006979	biological_process	response to oxidative stress
G	0008283	biological_process	cell population proliferation
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0019430	biological_process	removal of superoxide radicals
G	0020037	molecular_function	heme binding
G	0030101	biological_process	natural killer cell activation
G	0032872	biological_process	regulation of stress-activated MAPK cascade
G	0034101	biological_process	erythrocyte homeostasis
G	0042267	biological_process	natural killer cell mediated cytotoxicity
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0042802	molecular_function	identical protein binding
G	0045321	biological_process	leukocyte activation
G	0045454	biological_process	cell redox homeostasis
G	0051920	molecular_function	peroxiredoxin activity
G	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
H	0000302	biological_process	response to reactive oxygen species
H	0000791	cellular_component	euchromatin
H	0004601	molecular_function	peroxidase activity
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005759	cellular_component	mitochondrial matrix
H	0005782	cellular_component	peroxisomal matrix
H	0005829	cellular_component	cytosol
H	0006979	biological_process	response to oxidative stress
H	0008283	biological_process	cell population proliferation
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0019430	biological_process	removal of superoxide radicals
H	0020037	molecular_function	heme binding
H	0030101	biological_process	natural killer cell activation
H	0032872	biological_process	regulation of stress-activated MAPK cascade
H	0034101	biological_process	erythrocyte homeostasis
H	0042267	biological_process	natural killer cell mediated cytotoxicity
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0042802	molecular_function	identical protein binding
H	0045321	biological_process	leukocyte activation
H	0045454	biological_process	cell redox homeostasis
H	0051920	molecular_function	peroxiredoxin activity
H	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
I	0000302	biological_process	response to reactive oxygen species
I	0000791	cellular_component	euchromatin
I	0004601	molecular_function	peroxidase activity
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005759	cellular_component	mitochondrial matrix
I	0005782	cellular_component	peroxisomal matrix
I	0005829	cellular_component	cytosol
I	0006979	biological_process	response to oxidative stress
I	0008283	biological_process	cell population proliferation
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0019430	biological_process	removal of superoxide radicals
I	0020037	molecular_function	heme binding
I	0030101	biological_process	natural killer cell activation
I	0032872	biological_process	regulation of stress-activated MAPK cascade
I	0034101	biological_process	erythrocyte homeostasis
I	0042267	biological_process	natural killer cell mediated cytotoxicity
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0042802	molecular_function	identical protein binding
I	0045321	biological_process	leukocyte activation
I	0045454	biological_process	cell redox homeostasis
I	0051920	molecular_function	peroxiredoxin activity
I	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
J	0000302	biological_process	response to reactive oxygen species
J	0000791	cellular_component	euchromatin
J	0004601	molecular_function	peroxidase activity
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005759	cellular_component	mitochondrial matrix
J	0005782	cellular_component	peroxisomal matrix
J	0005829	cellular_component	cytosol
J	0006979	biological_process	response to oxidative stress
J	0008283	biological_process	cell population proliferation
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0019430	biological_process	removal of superoxide radicals
J	0020037	molecular_function	heme binding
J	0030101	biological_process	natural killer cell activation
J	0032872	biological_process	regulation of stress-activated MAPK cascade
J	0034101	biological_process	erythrocyte homeostasis
J	0042267	biological_process	natural killer cell mediated cytotoxicity
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0042802	molecular_function	identical protein binding
J	0045321	biological_process	leukocyte activation
J	0045454	biological_process	cell redox homeostasis
J	0051920	molecular_function	peroxiredoxin activity
J	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1590
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q06830","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	30
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q06830","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q06830","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	10
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P35700","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	10
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q06830","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P35700","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	10
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"Q06830","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"UniProtKB","id":"Q06830","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	10
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"Q06830","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)