Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004164 | molecular_function | diphthine synthase activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0017183 | biological_process | protein histidyl modification to diphthamide |
| A | 0032259 | biological_process | methylation |
| B | 0004164 | molecular_function | diphthine synthase activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0017183 | biological_process | protein histidyl modification to diphthamide |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1304 |
| Chain | Residue |
| A | ASN142 |
| B | HOH1707 |
| A | HOH1535 |
| A | HOH1631 |
| A | HOH1901 |
| B | PRO145 |
| B | THR146 |
| B | SER147 |
| B | HOH1561 |
| B | HOH1625 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1305 |
| Chain | Residue |
| A | THR43 |
| A | GLY45 |
| A | ARG49 |
| A | HOH1584 |
| A | HOH1661 |
| A | HOH1824 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1306 |
| Chain | Residue |
| A | TYR128 |
| A | LYS129 |
| A | HIS243 |
| A | HOH1851 |
| A | HOH1879 |
| B | ASN66 |
| B | LYS132 |
| B | HOH1646 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1307 |
| Chain | Residue |
| A | ARG258 |
| A | HOH1889 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1301 |
| Chain | Residue |
| B | THR43 |
| B | GLY45 |
| B | ARG46 |
| B | HOH1543 |
| B | HOH1552 |
| B | HOH1600 |
| B | HOH1642 |
| B | HOH1882 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1302 |
| Chain | Residue |
| B | ARG46 |
| B | LYS129 |
| B | LYS241 |
| B | HIS243 |
| B | HOH1548 |
| B | HOH1605 |
| B | HOH1612 |
| B | HOH1696 |
| B | HOH1837 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1303 |
| Chain | Residue |
| B | PRO257 |
| B | ARG258 |
| B | HOH1643 |
| B | HOH1727 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAH A 1300 |
| Chain | Residue |
| A | LEU10 |
| A | THR36 |
| A | SER37 |
| A | ASP87 |
| A | VAL90 |
| A | SER115 |
| A | ILE116 |
| A | PHE165 |
| A | LEU166 |
| A | LEU206 |
| A | ARG208 |
| A | ALA209 |
| A | PRO233 |
| A | HIS234 |
| A | ILE235 |
| A | HOH1522 |
| A | HOH1531 |
| A | HOH1540 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MES A 1501 |
| Chain | Residue |
| A | PHE34 |
| A | MET39 |
| A | THR42 |
| A | THR43 |
| A | LEU44 |
| A | VAL57 |
| A | HOH1614 |
| A | HOH1681 |
| A | HOH1866 |
| A | HOH1867 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MES B 1502 |
| Chain | Residue |
| B | PRO85 |
| B | GLY86 |
| B | SER115 |
| B | ILE116 |
| B | PHE165 |
| B | HOH1523 |
| B | HOH1546 |
| B | HOH1620 |
| B | HOH1621 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MES B 1503 |
| Chain | Residue |
| B | ASP200 |
| B | TYR220 |
| B | LYS222 |
| B | GLU259 |
| B | HOH1732 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1401 |
| Chain | Residue |
| B | PHE34 |
| B | LEU38 |
| B | MET39 |
| B | THR42 |
| B | THR43 |
| B | ARG173 |
| B | HOH1544 |
| B | HOH1613 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1402 |
| Chain | Residue |
| A | LEU212 |
| A | ASN213 |
| A | HOH1690 |
| A | TYR11 |
| A | SER211 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 1403 |
| Chain | Residue |
| A | VAL63 |
| A | GLU64 |
| A | LEU65 |
| A | PHE67 |
| A | GLU68 |
| A | LEU97 |
| A | ARG100 |
| A | HOH1637 |
| B | ARG49 |
| B | HOH1745 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | LEU10 | |
| B | VAL90 | |
| B | SER115 | |
| B | LEU166 | |
| B | ALA209 | |
| B | HIS234 | |
| A | ASP87 | |
| A | VAL90 | |
| A | SER115 | |
| A | LEU166 | |
| A | ALA209 | |
| A | HIS234 | |
| B | LEU10 | |
| B | ASP87 | |
