2Z6K

Crystal structure of full-length human RPA14/32 heterodimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000077	biological_process	DNA damage checkpoint signaling
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005662	cellular_component	DNA replication factor A complex
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0010569	biological_process	regulation of double-strand break repair via homologous recombination
A	0016604	cellular_component	nuclear body
A	0016605	cellular_component	PML body
A	0019899	molecular_function	enzyme binding
A	0019903	molecular_function	protein phosphatase binding
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0034502	biological_process	protein localization to chromosome
A	0035861	cellular_component	site of double-strand break
A	0042162	molecular_function	telomeric DNA binding
A	0098505	molecular_function	G-rich strand telomeric DNA binding
A	2000001	biological_process	regulation of DNA damage checkpoint
B	0000077	biological_process	DNA damage checkpoint signaling
B	0000723	biological_process	telomere maintenance
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005662	cellular_component	DNA replication factor A complex
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006289	biological_process	nucleotide-excision repair
B	0006298	biological_process	mismatch repair
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0010569	biological_process	regulation of double-strand break repair via homologous recombination
B	0016604	cellular_component	nuclear body
B	0016605	cellular_component	PML body
B	0019899	molecular_function	enzyme binding
B	0019903	molecular_function	protein phosphatase binding
B	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0034502	biological_process	protein localization to chromosome
B	0035861	cellular_component	site of double-strand break
B	0042162	molecular_function	telomeric DNA binding
B	0098505	molecular_function	G-rich strand telomeric DNA binding
B	2000001	biological_process	regulation of DNA damage checkpoint
C	0000723	biological_process	telomere maintenance
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005662	cellular_component	DNA replication factor A complex
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0006289	biological_process	nucleotide-excision repair
C	0006298	biological_process	mismatch repair
C	0006310	biological_process	DNA recombination
C	0006974	biological_process	DNA damage response
C	0035861	cellular_component	site of double-strand break
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005662	cellular_component	DNA replication factor A complex
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006289	biological_process	nucleotide-excision repair
D	0006298	biological_process	mismatch repair
D	0006310	biological_process	DNA recombination
D	0006974	biological_process	DNA damage response
D	0035861	cellular_component	site of double-strand break

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N-acetylvaline","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"26474068","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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