2Z64
Crystal structure of mouse TLR4 and mouse MD-2 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0001530 | molecular_function | lipopolysaccharide binding |
| C | 0001875 | molecular_function | lipopolysaccharide immune receptor activity |
| C | 0002221 | biological_process | pattern recognition receptor signaling pathway |
| C | 0002224 | biological_process | toll-like receptor signaling pathway |
| C | 0002376 | biological_process | immune system process |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006954 | biological_process | inflammatory response |
| C | 0031663 | biological_process | lipopolysaccharide-mediated signaling pathway |
| C | 0031666 | biological_process | positive regulation of lipopolysaccharide-mediated signaling pathway |
| C | 0032496 | biological_process | response to lipopolysaccharide |
| C | 0032497 | biological_process | detection of lipopolysaccharide |
| C | 0032760 | biological_process | positive regulation of tumor necrosis factor production |
| C | 0034142 | biological_process | toll-like receptor 4 signaling pathway |
| C | 0035662 | molecular_function | Toll-like receptor 4 binding |
| C | 0043235 | cellular_component | receptor complex |
| C | 0045087 | biological_process | innate immune response |
| C | 0046696 | cellular_component | lipopolysaccharide receptor complex |
| C | 0071222 | biological_process | cellular response to lipopolysaccharide |
Functional Information from PROSITE/UniProt
| site_id | PS00159 |
| Number of Residues | 10 |
| Details | ALDOLASE_KDPG_KHG_1 KDPG and KHG aldolases active site. GIklhELTLR |
| Chain | Residue | Details |
| A | GLY224-ARG233 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 10","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 11","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 12","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"LRR 13","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 14","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 15","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 16","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 17","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 18","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 19","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 11 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 4 |
| Details | Region: {"description":"Interaction with lipopolysaccharide","evidences":[{"source":"UniProtKB","id":"Q9Y6Y9","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"22532668","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Z64","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
