2Z49
Crystal Structure of Hemolytic Lectin CEL-III Complexed with methyl-alpha-D-galactopylanoside
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0001906 | biological_process | cell killing |
| A | 0004653 | molecular_function | polypeptide N-acetylgalactosaminyltransferase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005534 | molecular_function | galactose binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006493 | biological_process | protein O-linked glycosylation |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0030395 | molecular_function | lactose binding |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0034120 | biological_process | positive regulation of erythrocyte aggregation |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042806 | molecular_function | fucose binding |
| A | 0044179 | biological_process | hemolysis in another organism |
| A | 0046871 | molecular_function | N-acetylgalactosamine binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0051673 | biological_process | disruption of plasma membrane integrity in another organism |
| A | 1903777 | molecular_function | melibiose binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0001906 | biological_process | cell killing |
| B | 0004653 | molecular_function | polypeptide N-acetylgalactosaminyltransferase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005534 | molecular_function | galactose binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006493 | biological_process | protein O-linked glycosylation |
| B | 0019731 | biological_process | antibacterial humoral response |
| B | 0030246 | molecular_function | carbohydrate binding |
| B | 0030395 | molecular_function | lactose binding |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0034120 | biological_process | positive regulation of erythrocyte aggregation |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0042806 | molecular_function | fucose binding |
| B | 0044179 | biological_process | hemolysis in another organism |
| B | 0046871 | molecular_function | N-acetylgalactosamine binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0051260 | biological_process | protein homooligomerization |
| B | 0051673 | biological_process | disruption of plasma membrane integrity in another organism |
| B | 1903777 | molecular_function | melibiose binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 148 |
| Details | Domain: {"description":"Ricin B-type lectin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 260 |
| Details | Domain: {"description":"Ricin B-type lectin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | Domain: {"description":"Ricin B-type lectin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 586 |
| Details | Region: {"description":"Has hemagglutinating activity towards rabbit erythrocytes, but no hemolytic activity towards them","evidences":[{"source":"PubMed","id":"19420692","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17977832","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Z48","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17977832","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24652284","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Z48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W9T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15194688","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17977832","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24652284","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1VCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Z49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W9T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17977832","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24652284","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Z49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W9T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"10561549","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15194688","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
