2Z2Y

Crystal structure of autoprocessed form of Tk-subtilisin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1001

Chain	Residue
A	GLN84
A	ASP124
A	LEU164
A	ASN166
A	ILE168
A	VAL170

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1002

Chain	Residue
A	ASP226
A	HOH2081
A	HOH2130
A	LEU205
A	ASP208
A	VAL210

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 1003

Chain	Residue
A	ASP212
A	ASP214
A	ASP216
A	ILE218
A	ASP222
A	ASP225
A	CA1004

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1004

Chain	Residue
A	ASP214
A	ASP216
A	ASP222
A	CA1003
D	HIS20

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1005

Chain	Residue
A	VAL108
A	GLN110
A	ALA227
A	GLU229
A	HOH2008
A	HOH2195

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1006

Chain	Residue
A	ASP372
A	LEU373
A	PRO375
A	GLY377
A	ASP379
A	HOH2036

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1007

Chain	Residue
A	ASP119
A	ASP121
A	ASP314
A	ASP315
A	HOH2152
A	HOH2221

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1008

Chain	Residue
C	GLN84
C	ASP124
C	LEU164
C	ASN166
C	ILE168
C	VAL170

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1009

Chain	Residue
C	LEU205
C	ASP208
C	VAL210
C	ASP226
C	HOH2063
C	HOH2085

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 1010

Chain	Residue
C	ASP212
C	ASP214
C	ASP216
C	ILE218
C	ASP222
C	ASP225
C	CA1011

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1011

Chain	Residue
B	HIS20
C	ASP214
C	ASP216
C	ASP222
C	CA1010

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1012

Chain	Residue
C	VAL108
C	GLN110
C	ALA227
C	GLU229
C	HOH2013
C	HOH2180

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1013

Chain	Residue
C	ASP372
C	LEU373
C	PRO375
C	GLY377
C	ASP379
C	HOH2028

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1014

Chain	Residue
C	ASP119
C	ASP121
C	ASP314
C	ASP315
C	HOH2095
C	HOH2193

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2001

Chain	Residue
A	HIS153
A	CYS324
B	LEU69
B	HOH2027

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2002

Chain	Residue
B	GLU61
B	HIS64
B	HOH2037
C	GLU318

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2003

Chain	Residue
C	HIS153
C	CYS324
D	LEU69
D	HOH2034

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 2004

Chain	Residue
D	HIS64
A	GLU318
A	HOH2005
D	GLU61

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 2005

Chain	Residue
C	HOH2184
D	HIS28
D	ASP42

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 2006

Chain	Residue
A	HOH2257
B	HIS28
B	ASP42

---

Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VAVLDTGVdydH

Chain	Residue	Details
A	VAL111-HIS122

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240

Chain	Residue	Details
A	ASP115
A	HIS153
A	CYS324
C	ASP115
C	HIS153
C	CYS324

---