2Z1B

Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001666	biological_process	response to hypoxia
A	0003824	molecular_function	catalytic activity
A	0004655	molecular_function	porphobilinogen synthase activity
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0006779	biological_process	porphyrin-containing compound biosynthetic process
A	0006782	biological_process	protoporphyrinogen IX biosynthetic process
A	0006783	biological_process	heme biosynthetic process
A	0006784	biological_process	heme A biosynthetic process
A	0006785	biological_process	heme B biosynthetic process
A	0006979	biological_process	response to oxidative stress
A	0007584	biological_process	response to nutrient
A	0008270	molecular_function	zinc ion binding
A	0009410	biological_process	response to xenobiotic stimulus
A	0009635	biological_process	response to herbicide
A	0009636	biological_process	response to toxic substance
A	0009725	biological_process	response to hormone
A	0010038	biological_process	response to metal ion
A	0010039	biological_process	response to iron ion
A	0010043	biological_process	response to zinc ion
A	0010044	biological_process	response to aluminum ion
A	0010212	biological_process	response to ionizing radiation
A	0010266	biological_process	response to vitamin B1
A	0010269	biological_process	response to selenium ion
A	0010288	biological_process	response to lead ion
A	0014823	biological_process	response to activity
A	0016829	molecular_function	lyase activity
A	0031667	biological_process	response to nutrient levels
A	0032025	biological_process	response to cobalt ion
A	0032496	biological_process	response to lipopolysaccharide
A	0032791	molecular_function	lead ion binding
A	0033014	biological_process	tetrapyrrole biosynthetic process
A	0033197	biological_process	response to vitamin E
A	0033273	biological_process	response to vitamin
A	0042802	molecular_function	identical protein binding
A	0043200	biological_process	response to amino acid
A	0045471	biological_process	response to ethanol
A	0046685	biological_process	response to arsenic-containing substance
A	0046686	biological_process	response to cadmium ion
A	0046689	biological_process	response to mercury ion
A	0046872	molecular_function	metal ion binding
A	0051260	biological_process	protein homooligomerization
A	0051384	biological_process	response to glucocorticoid
A	0051597	biological_process	response to methylmercury
A	0070541	biological_process	response to platinum ion
A	0070542	biological_process	response to fatty acid
A	0071284	biological_process	cellular response to lead ion
A	0071353	biological_process	cellular response to interleukin-4
A	1901799	biological_process	negative regulation of proteasomal protein catabolic process
A	1904854	molecular_function	proteasome core complex binding
B	0001666	biological_process	response to hypoxia
B	0003824	molecular_function	catalytic activity
B	0004655	molecular_function	porphobilinogen synthase activity
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0006779	biological_process	porphyrin-containing compound biosynthetic process
B	0006782	biological_process	protoporphyrinogen IX biosynthetic process
B	0006783	biological_process	heme biosynthetic process
B	0006784	biological_process	heme A biosynthetic process
B	0006785	biological_process	heme B biosynthetic process
B	0006979	biological_process	response to oxidative stress
B	0007584	biological_process	response to nutrient
B	0008270	molecular_function	zinc ion binding
B	0009410	biological_process	response to xenobiotic stimulus
B	0009635	biological_process	response to herbicide
B	0009636	biological_process	response to toxic substance
B	0009725	biological_process	response to hormone
B	0010038	biological_process	response to metal ion
B	0010039	biological_process	response to iron ion
B	0010043	biological_process	response to zinc ion
B	0010044	biological_process	response to aluminum ion
B	0010212	biological_process	response to ionizing radiation
B	0010266	biological_process	response to vitamin B1
B	0010269	biological_process	response to selenium ion
B	0010288	biological_process	response to lead ion
B	0014823	biological_process	response to activity
B	0016829	molecular_function	lyase activity
B	0031667	biological_process	response to nutrient levels
B	0032025	biological_process	response to cobalt ion
B	0032496	biological_process	response to lipopolysaccharide
B	0032791	molecular_function	lead ion binding
B	0033014	biological_process	tetrapyrrole biosynthetic process
B	0033197	biological_process	response to vitamin E
B	0033273	biological_process	response to vitamin
B	0042802	molecular_function	identical protein binding
B	0043200	biological_process	response to amino acid
B	0045471	biological_process	response to ethanol
B	0046685	biological_process	response to arsenic-containing substance
B	0046686	biological_process	response to cadmium ion
B	0046689	biological_process	response to mercury ion
B	0046872	molecular_function	metal ion binding
B	0051260	biological_process	protein homooligomerization
B	0051384	biological_process	response to glucocorticoid
B	0051597	biological_process	response to methylmercury
B	0070541	biological_process	response to platinum ion
B	0070542	biological_process	response to fatty acid
B	0071284	biological_process	cellular response to lead ion
B	0071353	biological_process	cellular response to interleukin-4
B	1901799	biological_process	negative regulation of proteasomal protein catabolic process
B	1904854	molecular_function	proteasome core complex binding
C	0001666	biological_process	response to hypoxia
C	0003824	molecular_function	catalytic activity
C	0004655	molecular_function	porphobilinogen synthase activity
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0006779	biological_process	porphyrin-containing compound biosynthetic process
C	0006782	biological_process	protoporphyrinogen IX biosynthetic process
C	0006783	biological_process	heme biosynthetic process
C	0006784	biological_process	heme A biosynthetic process
C	0006785	biological_process	heme B biosynthetic process
C	0006979	biological_process	response to oxidative stress
C	0007584	biological_process	response to nutrient
C	0008270	molecular_function	zinc ion binding
C	0009410	biological_process	response to xenobiotic stimulus
C	0009635	biological_process	response to herbicide
C	0009636	biological_process	response to toxic substance
C	0009725	biological_process	response to hormone
C	0010038	biological_process	response to metal ion
C	0010039	biological_process	response to iron ion
C	0010043	biological_process	response to zinc ion
C	0010044	biological_process	response to aluminum ion
C	0010212	biological_process	response to ionizing radiation
C	0010266	biological_process	response to vitamin B1
C	0010269	biological_process	response to selenium ion
C	0010288	biological_process	response to lead ion
C	0014823	biological_process	response to activity
C	0016829	molecular_function	lyase activity
C	0031667	biological_process	response to nutrient levels
C	0032025	biological_process	response to cobalt ion
C	0032496	biological_process	response to lipopolysaccharide
C	0032791	molecular_function	lead ion binding
C	0033014	biological_process	tetrapyrrole biosynthetic process
C	0033197	biological_process	response to vitamin E
C	0033273	biological_process	response to vitamin
C	0042802	molecular_function	identical protein binding
C	0043200	biological_process	response to amino acid
C	0045471	biological_process	response to ethanol
C	0046685	biological_process	response to arsenic-containing substance
C	0046686	biological_process	response to cadmium ion
C	0046689	biological_process	response to mercury ion
C	0046872	molecular_function	metal ion binding
C	0051260	biological_process	protein homooligomerization
C	0051384	biological_process	response to glucocorticoid
C	0051597	biological_process	response to methylmercury
C	0070541	biological_process	response to platinum ion
C	0070542	biological_process	response to fatty acid
C	0071284	biological_process	cellular response to lead ion
C	0071353	biological_process	cellular response to interleukin-4
C	1901799	biological_process	negative regulation of proteasomal protein catabolic process
C	1904854	molecular_function	proteasome core complex binding
D	0001666	biological_process	response to hypoxia
D	0003824	molecular_function	catalytic activity
D	0004655	molecular_function	porphobilinogen synthase activity
D	0005615	cellular_component	extracellular space
D	0005829	cellular_component	cytosol
D	0006779	biological_process	porphyrin-containing compound biosynthetic process
D	0006782	biological_process	protoporphyrinogen IX biosynthetic process
D	0006783	biological_process	heme biosynthetic process
D	0006784	biological_process	heme A biosynthetic process
D	0006785	biological_process	heme B biosynthetic process
D	0006979	biological_process	response to oxidative stress
D	0007584	biological_process	response to nutrient
D	0008270	molecular_function	zinc ion binding
D	0009410	biological_process	response to xenobiotic stimulus
D	0009635	biological_process	response to herbicide
D	0009636	biological_process	response to toxic substance
D	0009725	biological_process	response to hormone
D	0010038	biological_process	response to metal ion
D	0010039	biological_process	response to iron ion
D	0010043	biological_process	response to zinc ion
D	0010044	biological_process	response to aluminum ion
D	0010212	biological_process	response to ionizing radiation
D	0010266	biological_process	response to vitamin B1
D	0010269	biological_process	response to selenium ion
D	0010288	biological_process	response to lead ion
D	0014823	biological_process	response to activity
D	0016829	molecular_function	lyase activity
D	0031667	biological_process	response to nutrient levels
D	0032025	biological_process	response to cobalt ion
D	0032496	biological_process	response to lipopolysaccharide
D	0032791	molecular_function	lead ion binding
D	0033014	biological_process	tetrapyrrole biosynthetic process
D	0033197	biological_process	response to vitamin E
D	0033273	biological_process	response to vitamin
D	0042802	molecular_function	identical protein binding
D	0043200	biological_process	response to amino acid
D	0045471	biological_process	response to ethanol
D	0046685	biological_process	response to arsenic-containing substance
D	0046686	biological_process	response to cadmium ion
D	0046689	biological_process	response to mercury ion
D	0046872	molecular_function	metal ion binding
D	0051260	biological_process	protein homooligomerization
D	0051384	biological_process	response to glucocorticoid
D	0051597	biological_process	response to methylmercury
D	0070541	biological_process	response to platinum ion
D	0070542	biological_process	response to fatty acid
D	0071284	biological_process	cellular response to lead ion
D	0071353	biological_process	cellular response to interleukin-4
D	1901799	biological_process	negative regulation of proteasomal protein catabolic process
D	1904854	molecular_function	proteasome core complex binding

Functional Information from PROSITE/UniProt

site_id	PS00169
Number of Residues	13
Details	D_ALA_DEHYDRATASE Delta-aminolevulinic acid dehydratase active site. GaDmLMVKPGlpY

Chain	Residue	Details
A	GLY245-TYR257

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1h7o

Chain	Residue	Details
A	LYS199
A	ASP120
A	LYS252
A	SER168

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1h7o

Chain	Residue	Details
B	LYS199
B	ASP120
B	LYS252
B	SER168

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1h7o

Chain	Residue	Details
C	LYS199
C	ASP120
C	LYS252
C	SER168

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1h7o

Chain	Residue	Details
D	LYS199
D	ASP120
D	LYS252
D	SER168

---