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2Z0I

Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculus

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0003824molecular_functioncatalytic activity
A0004655molecular_functionporphobilinogen synthase activity
A0005615cellular_componentextracellular space
A0005829cellular_componentcytosol
A0006779biological_processporphyrin-containing compound biosynthetic process
A0006782biological_processprotoporphyrinogen IX biosynthetic process
A0006783biological_processheme biosynthetic process
A0006784biological_processheme A biosynthetic process
A0006785biological_processheme B biosynthetic process
A0006979biological_processresponse to oxidative stress
A0007584biological_processresponse to nutrient
A0008152biological_processmetabolic process
A0008270molecular_functionzinc ion binding
A0009410biological_processresponse to xenobiotic stimulus
A0009635biological_processresponse to herbicide
A0009636biological_processresponse to toxic substance
A0009725biological_processresponse to hormone
A0010033biological_processresponse to organic substance
A0010035biological_processresponse to inorganic substance
A0010038biological_processresponse to metal ion
A0010039biological_processresponse to iron ion
A0010043biological_processresponse to zinc ion
A0010044biological_processresponse to aluminum ion
A0010212biological_processresponse to ionizing radiation
A0010266biological_processresponse to vitamin B1
A0010269biological_processresponse to selenium ion
A0010288biological_processresponse to lead ion
A0014070biological_processresponse to organic cyclic compound
A0014823biological_processresponse to activity
A0016829molecular_functionlyase activity
A0031667biological_processresponse to nutrient levels
A0032025biological_processresponse to cobalt ion
A0032496biological_processresponse to lipopolysaccharide
A0033014biological_processtetrapyrrole biosynthetic process
A0033197biological_processresponse to vitamin E
A0033273biological_processresponse to vitamin
A0042802molecular_functionidentical protein binding
A0043200biological_processresponse to amino acid
A0045471biological_processresponse to ethanol
A0046685biological_processresponse to arsenic-containing substance
A0046686biological_processresponse to cadmium ion
A0046689biological_processresponse to mercury ion
A0046872molecular_functionmetal ion binding
A0048034biological_processheme O biosynthetic process
A0051260biological_processprotein homooligomerization
A0051384biological_processresponse to glucocorticoid
A0051597biological_processresponse to methylmercury
A0070541biological_processresponse to platinum ion
A0070542biological_processresponse to fatty acid
A0071284biological_processcellular response to lead ion
A0071353biological_processcellular response to interleukin-4
A1901799biological_processnegative regulation of proteasomal protein catabolic process
A1904854molecular_functionproteasome core complex binding
B0001666biological_processresponse to hypoxia
B0003824molecular_functioncatalytic activity
B0004655molecular_functionporphobilinogen synthase activity
B0005615cellular_componentextracellular space
B0005829cellular_componentcytosol
B0006779biological_processporphyrin-containing compound biosynthetic process
B0006782biological_processprotoporphyrinogen IX biosynthetic process
B0006783biological_processheme biosynthetic process
B0006784biological_processheme A biosynthetic process
B0006785biological_processheme B biosynthetic process
B0006979biological_processresponse to oxidative stress
B0007584biological_processresponse to nutrient
B0008152biological_processmetabolic process
B0008270molecular_functionzinc ion binding
B0009410biological_processresponse to xenobiotic stimulus
B0009635biological_processresponse to herbicide
B0009636biological_processresponse to toxic substance
B0009725biological_processresponse to hormone
B0010033biological_processresponse to organic substance
B0010035biological_processresponse to inorganic substance
B0010038biological_processresponse to metal ion
B0010039biological_processresponse to iron ion
B0010043biological_processresponse to zinc ion
B0010044biological_processresponse to aluminum ion
B0010212biological_processresponse to ionizing radiation
B0010266biological_processresponse to vitamin B1
B0010269biological_processresponse to selenium ion
B0010288biological_processresponse to lead ion
B0014070biological_processresponse to organic cyclic compound
B0014823biological_processresponse to activity
B0016829molecular_functionlyase activity
B0031667biological_processresponse to nutrient levels
B0032025biological_processresponse to cobalt ion
B0032496biological_processresponse to lipopolysaccharide
B0033014biological_processtetrapyrrole biosynthetic process
B0033197biological_processresponse to vitamin E
B0033273biological_processresponse to vitamin
B0042802molecular_functionidentical protein binding
B0043200biological_processresponse to amino acid
B0045471biological_processresponse to ethanol
B0046685biological_processresponse to arsenic-containing substance
B0046686biological_processresponse to cadmium ion
B0046689biological_processresponse to mercury ion
B0046872molecular_functionmetal ion binding
B0048034biological_processheme O biosynthetic process
B0051260biological_processprotein homooligomerization
B0051384biological_processresponse to glucocorticoid
B0051597biological_processresponse to methylmercury
B0070541biological_processresponse to platinum ion
B0070542biological_processresponse to fatty acid
B0071284biological_processcellular response to lead ion
B0071353biological_processcellular response to interleukin-4
B1901799biological_processnegative regulation of proteasomal protein catabolic process
B1904854molecular_functionproteasome core complex binding
Functional Information from PROSITE/UniProt
site_idPS00169
Number of Residues13
DetailsD_ALA_DEHYDRATASE Delta-aminolevulinic acid dehydratase active site. GaDmLMVKPGlpY
ChainResidueDetails
AGLY245-TYR257

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Schiff-base intermediate with substrate => ECO:0000250
ChainResidueDetails
ALYS199
ALYS252
BLYS199
BLYS252

site_idSWS_FT_FI2
Number of Residues18
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ACYS122
BCYS122
BCYS124
BHIS131
BCYS132
BARG209
BARG221
BCYS223
BSER279
BTYR318
ACYS124
AHIS131
ACYS132
AARG209
AARG221
ACYS223
ASER279
ATYR318

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337
ChainResidueDetails
ALYS199
ALYS252
BLYS199
BLYS252

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER215
BSER215

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PDB entries from 2024-04-24

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