2YZD

Crystal structure of uricase from Arthrobacter globiformis in complex with 8-azaxanthin (inhibitor)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004846	molecular_function	urate oxidase activity
A	0006144	biological_process	purine nucleobase metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019628	biological_process	urate catabolic process
B	0004846	molecular_function	urate oxidase activity
B	0006144	biological_process	purine nucleobase metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0019628	biological_process	urate catabolic process
C	0004846	molecular_function	urate oxidase activity
C	0006144	biological_process	purine nucleobase metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0019628	biological_process	urate catabolic process
D	0004846	molecular_function	urate oxidase activity
D	0006144	biological_process	purine nucleobase metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0019628	biological_process	urate catabolic process
E	0004846	molecular_function	urate oxidase activity
E	0006144	biological_process	purine nucleobase metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0019628	biological_process	urate catabolic process
F	0004846	molecular_function	urate oxidase activity
F	0006144	biological_process	purine nucleobase metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0019628	biological_process	urate catabolic process
G	0004846	molecular_function	urate oxidase activity
G	0006144	biological_process	purine nucleobase metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0019628	biological_process	urate catabolic process
H	0004846	molecular_function	urate oxidase activity
H	0006144	biological_process	purine nucleobase metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0019628	biological_process	urate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AZA A 1301

Chain	Residue
A	PHE163
D	ALA66
D	THR67
A	LEU174
A	ARG180
A	ALA221
A	LEU222
A	GLN223
A	ASN249
A	HOH1428
D	TYR20

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AZA D 1302

Chain	Residue
A	TYR20
A	ALA66
A	THR67
D	PHE163
D	ARG180
D	ALA221
D	LEU222
D	GLN223
D	ASN249

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AZA B 1303

Chain	Residue
B	PHE163
B	LEU174
B	ARG180
B	ALA221
B	LEU222
B	GLN223
B	ASN249
C	TYR20
C	ALA66
C	THR67

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AZA C 1304

Chain	Residue
B	TYR20
B	ALA66
B	THR67
C	PHE163
C	LEU174
C	ARG180
C	ALA221
C	LEU222
C	GLN223
C	ASN249
C	HOH1378

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AZA E 1305

Chain	Residue
E	PHE163
E	ARG180
E	ALA221
E	LEU222
E	GLN223
E	ASN249
E	HOH1363
H	TYR20
H	THR67

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AZA H 1306

Chain	Residue
E	TYR20
E	THR67
H	PHE163
H	LEU174
H	ARG180
H	ALA221
H	LEU222
H	GLN223
H	ASN249
H	HOH1410

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AZA F 1307

Chain	Residue
F	PHE163
F	LEU174
F	ARG180
F	ALA221
F	LEU222
F	GLN223
F	ASN249
F	HOH1335
G	TYR20
G	ALA66
G	THR67

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AZA G 1308

Chain	Residue
F	TYR20
F	ALA66
F	THR67
G	PHE163
G	LEU174
G	ARG180
G	ALA221
G	LEU222
G	GLN223
G	ASN249
G	HOH1386

---

Functional Information from PROSITE/UniProt

site_id	PS00366
Number of Residues	28
Details	URICASE Uricase signature. LtVLKSTgSeFhgFprdkYttLqettdR

Chain	Residue	Details
A	LEU153-ARG180

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"18645230","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18645230","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2YZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YZC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00511","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
A	ARG180
A	GLN223

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
B	ARG180
B	GLN223

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
C	ARG180
C	GLN223

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
D	ARG180
D	GLN223

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
E	ARG180
E	GLN223

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
F	ARG180
F	GLN223

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
G	ARG180
G	GLN223

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
H	ARG180
H	GLN223

---